Noninvasive prenatal testing, ultrasonographic findings and poor prenatal diagnosis rates for twin pregnancies: a retrospective study

Table 1 The clinical and laboratory data of 14 twin pregnancies with NIPT results indicating high risk

Case no.	MA	GW	Chorionicity	NIPT Results	USG Findings	PD Method	PD Results	Outcomes
1	33	20^+ 5	DCDA	T21	TwinA: embryo arrest at 9 GW TwinB:N	AC	TwinB:N	TwinB:LB
2	38	16^+ 2	MCDA	T21	TwinA and TwinB:N	AC	TwinA and TwinB:T21	TwinA and TwinB:TOP
3	33	19^+ 3	DCDA	T21	TwinA:N TwinB:FGR, PH	AC	TwinA:N TwinB:T21	TwinA:LB TwinB:FR
4	36	15^+ 3	DCDA	T21	TwinA and TwinB:N	AC	TwinA:T21 TwinB:N	TwinA:FR TwinB:LB
5	24	23^+ 3	DCDA	T18	TwinA:embryo arrest at 12 GW TwinB:N	AC	TwinB:N	TwinB:LB
6	28	15^+ 5	DCDA	XXY	TwinA and TwinB:N	AC	TwinA:N TwinB:47,XXY	TwinA:LB^a TwinB:FR
7	29	16	DCDA	XXY	TwinA and TwinB:N	AC	TwinA:47,XXY TwinB:N	TwinA and TwinB:SA
8	28	19^+ 1	DCDA	XXX	TwinA and TwinB:N	AC	TwinA and TwinB:N	TwinA and TwinB:LB
9	33	16^+ 1	DCDA	XO	TwinA and TwinB:N	AC	TwinA and TwinB:N	TwinA and TwinB:LB
10	25	18^+ 4	DCDA	11q14.3-q25 deletion (45 Mb)	TwinA and TwinB:N	AC	TwinA and TwinB:N	TwinA and TwinB:LB
11	33	16^+ 6	DCDA	DiGeorge syndrome	TwinA:N TwinB:ARSA	AC	TwinA and TwinB:N	TwinA and TwinB:LB
12	23	16^+ 1	DCDA	XXX	TwinA and TwinB:N	-	-	TwinA and TwinB:LB
13	34	16^+ 2	DCDA	15q21.3-q23 deletion (10 Mb)	TwinA and TwinB:N	-	-	TwinA and TwinB:LB
14	28	16	MCDA	T7	TwinA and TwinB:N	-	-	TwinA and TwinB:LB

AC:amniocentesis; ARSA:aberrant right subclavian artery; DCDA: dichorionic diamnion; FGR:fetal growth restriction; FR:fetal reduction; GW:gestational weeks; LB: live birth; MA: maternal age; MCDA: monochorionic diamnion; N: normal; PD: prenatal diagnosis; PH: polyhydramnios; SA: spontaneous abortion; T: trisomy; TOP: termination of pregnancy; USG: ultrasonographic
^a:The infant was diagnosed with congenital carnitine deficiency at age two

ISSN: 1471-2393