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Table 3 Association of maternal lipid profile in second trimester of pregnancy with adverse pregnancy outcomes among GDM and non-GDM group

From: Association between second- and third-trimester maternal lipid profiles and adverse perinatal outcomes among women with GDM and non-GDM: a retrospective cohort study

 

TC, AOR (95%CI)

TG, AOR (95%CI)

LDL, AOR (95%CI)

HDL, AOR (95%CI)

 

GDM-group

non-GDM-group

P

GDM-group

non-GDM-group

P

GDM-group

non-GDM-group

P

GDM-group

non-GDM-group

P

Maternal outcome

 Caesarean delivery

0.908(0.756–1.102)

1.034(0.798–1.432)

0.879

1.423(1.215–1.679)***

1.107(1.071–1.236)*

0.002

0.938(0.668–1.132)

0.971(0.673–1.324)

0.921

0.719(0.573–1.214)

1.146(0.873–1.532)

0.569

 PROM

0.913(0.703–1.109)

0.849(.0723–1.431)

0.912

1.204(0.887–1.275)

1.021(0.865–1.342)

0.694

0.836(0.689–1.205)

1.252(0.759–1.625)

0.674

1.098(0.699–1.598)

0.913(0.651–1.517)

0.774

 Preterm birth

0.764(0.671–1.122)

0.961(0.832–1.335)

0.734

1.199(0.873–1.516)

0.872(0.776–1.213)

0.453

1.124(0.793–1.089)

0.921(0.746–1.432)

0.763

0.725(0.528–1.235)

1.052(0.411–1.108)

0.482

 Abruptio placentae

0.903(0.612–1.156)

1.319(0.768–1.564)

0.583

0.429(0.319–0.799)*

0.912(0.823–1.158)

0.023

1.103(0.593–1.624)

1.123(0.799–1.581)

0.883

0.813(0.584–1.479)

0.745(0.569–1.715)

0.832

 PPH

1.084(0.803–1.124)

1.113(0.921–1.263)

0.832

0.931(0.587–1.372)

1.231(0.894–1.498)

0.328

0.979(0.702–1.316)

1.322(0.941–1.582)

0.549

1.012(0.513–2.025)

1.291(0.795–1.729)

0.799

Neonatal outcome

 LGA

1.162(0.742–2.102)

1.214(0.921–1.414)

0.794

1.593(1.235–2.518)**

1.213(1.081–1.764)*

0.012

1.589(0.794–2.212)

1.453(0.799–1.756)

0.923

0.421(0.353–0.712)**

0.612(0.438–0.901)*

0.017

 SGA

0.823(0.513–1.254)

0.941(0.751–1.328)

0.802

1.029(0.781–1.703)

1.216(0.879–1.763)

0.332

1.489(0.829–2.587)

1.463(0.912–2.031)

0.996

0.876(0.512–3.136)

0.796(0.405–3.489)

0.913

 Macrosomia

0.906(0.624–1.246)

1.231(0.832–1.521)

0.495

1.346(1.209–1.735)**

1.109(0.887–1.543)

0.008

1.029(0.796–1.232)

1.293(0.773–1.841)

0.794

0.815(0.512–1.423)

0.782(0.441–1.387)

0.956

 LBW

0.783(0.414–1.095)

0.816(0.712–1.234)

0.793

0.819(0.426–1.652)

0.892(0.667–1.496)

0.836

1.402(0.696–2.413)

0.992(0.759–1.569)

0.293

1.048(0.492–3.928)

0.987(0.240–4.054)

0.899

 NUD

1.318(0.726–1.786)

1.236(0.814–1.697)

0.811

1.936(1.453–2.546)***

1.263(1.189–1.423)*

0.002

1.498(0.823–1.893)

1.318(0.697–1.894)

0.885

0.532(0.327–0.773)*

0.728(0.626–1.325)

0.022

  1. AOR (95% CI) was adjusted for age, pre-pregnancy BMI, gestational weight gain, parity, IVF, caesarean history and abortion history by multivariate analyses
  2. GDM Gestational Diabetes Mellitus, TC Total cholesterol, TG Triglyceride, LDL Low density lipoprotein, HDL High density lipoprotein, AOR Adjusted odds ratio, PROM Premature rupture of the membranes, PPH Postpartum hemorrhage, LGA Large for gestational age, SGA Small for gestational age, LBW Low birth weight, NUD Neonatal unit admission. *** p < 0.001, ** p < 0.01, *p < 0.05,
  3. P value for the interaction to compare the relative risk between GDM and non-GDM women