Table 1 Characteristics and median MoM values of the Quadruple test

Maternal characteristic (Median, IQR)

Maternal age, year

31.5 (28,34)

30 (28,33)

0.061

BMI (Kg/m²)

25.1 (22.6,26.8)

22 (19.8,24.7)

< 0.001*

Gravidity

2 (1,2)

2 (1,2)

0.422

Parity

0 (0,1)

0 (0,1)

0.467

Gestational age at delivery, weeks

37.3 (35.6,38.4)

38.7 (38,39.7)

< 0.001*

Date of blood specimen collection

116 (112,120)

117 (111,121)

0.758

Hospital stays

5 (4,6)

4 (3,4)

< 0.001*

Obstetric characteristic (Percent)

Family history of preeclampsia

0 (0.00)

1 (0.05)

1

History of preeclampsia

10 (18.18)

12 (0.61)

< 0.001*

History of infertility

4 (7.27)

12 (0.61)

0.077

History of GDM

6 (10.90)

12 (0.61)

< 0.001*

History of abortion

13(23.63)

368(18.90)

0.481

Previous preterm

4 (7.27)

21 (1.07)

< 0.001*

Previous fetal growth restriction

2 (3.636)

1 (0.05)

< 0.001*

Chronic hypertension

11 (20.00)

26 (1.33)

< 0.001*

Diabetes mellitus

3 (5.45)

3 (0.15)

< 0.001*

Renal disease

2 (3.63)

1 (0.05)

< 0.001*

Thyroid disease

4 (7.27)

27 (1.39)

0.003*

Cardiac disease

2 (3.63)

14 (0.72)

0.105

Autoimmune disease (SLE, APS)

1 (1.88)

7 (0.35)

0.545

GDM

13 (23.63)

145 (7.45)

< 0.001*

Fetal growth restriction

7 (12.72)

11 (0.56)

< 0.001*

Preterm labor

13 (23.64)

126 (6.45)

< 0.001*

Neonatal outcome (Percent)

Neonatal weight (median, IQR (g))

2760 (2272,3389)

3110 (2842,3380)

< 0.001*

1-min Apgar score

< 0.001*

≤ 5

3 (5.45)

40 (2.06)

> 5

52 (94.55)

1905 (97.94)

5-min Apgar score

≤ 5

2 (3.64)

9 (0.46)

> 5

53 (96.36)

1936 (99.54)

Admission to the NICU

9 (16.36)

32 (1.65)

< 0.001*

Median MoM values of the serum markers (Median, IQR)

MSAFP

1.1 (0.8,1.2)

1 (0.8,1.2)

0.149

uE3

1 (0.7,1.6)

1.1 (0.8,1.4)

0.849

hCG

1.1 (0.7,1.8)

0.9 (0.6,1.4)

0.046

Inhibin A

1.2 (0.8,1.9)

1 (0.6,1.3)

< 0.001*