Adverse infant outcomes following low-risk pregnancies in England: a retrospective cohort study

Table 1 Infant events of interest

Infant events of interest
Assessed during period as stated
Neonatal death (from birth to day 28)
Infant death (from day 29 to day 90)
Early onset infant sepsis (from day 0 to day 7)
Late onset infant sepsis (from day 8 to day 90)
Assessed from start of pregnancy until 90 days after birth
Major congenital anomalies^a
Minor congenital anomalies^a
Assessed from birth until 90 days after birth
Very low (300–999 g) and low (1 000–2 499 g) birth weight^b
Macrosomia (birth weight 4 001–7 000 g)^b
Small for gestational age
Large for gestational age

^aAs the classification of major and minor congenital anomalies is only provided as International Classification of Diseases, 10^th Revision (ICD-10) codes in the European Surveillance of Congenital Anomalies (EUROCAT) [21], Read codes in the Clinical Practice Research Datalink were mapped manually to ICD-10 codes, and congenital anomalies were then classified as major or minor applying EUROCAT definitions, with major congenital anomalies being defined as: a structural or functional defect of prenatal origin, present at the time of live birth or fetal demise, or in utero, and affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; and minor congenital anomalies being those with lesser medical, functional, or cosmetic consequences [22]. See Additional file 2 for the diagnostic codes
^bBirth weight was set to missing if < 300 g or > 7,000 g

ISSN: 1471-2393