Effect | Level | Period | Adjusteda | |||||||
---|---|---|---|---|---|---|---|---|---|---|
NMS | General health | Physical functioning | Role physical | Bodily pain | Vitality | Social functioning | Mental health | Role emotional | ||
β(95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | β (95%CI) | |||
Period | Early | reference | reference | reference | reference | reference | reference | reference | reference | |
Mid/late | 4.56 (4.29, 4.82) | − 0.48 (− 0.76, − 0.20) | 2.81 (2.48, 3.13) | − 3.31 (− 3.61, -3.00) | 3.37 (3.11, 3.63) | 2.11 (1.78, 2.45) | 0.51 (0.27, 0.75) | 1.63 (1.34, 1.91) | ||
NMS | 0 | Early | reference | reference | reference | reference | reference | reference | reference | reference |
1 | Early | 0.10 (− 0.03, 0.24) | − 0.43 (− 0.57, − 0.28) | − 0.51 (− 0.68, − 0.34) | − 0.06 (− 0.21, 0.10) | − 0.09 (− 0.22, 0.05) | − 0.41 (− 0.59, − 0.24) | − 0.18 (− 0.31, − 0.05) | − 0.15 (− 0.30, 0.01) | |
2 | Early | 0.10 (− 0.17, 0.38) | − 0.73 (− 1.03, − 0.42) | − 0.75 (− 1.10, − 0.39) | − 0.10 (− 0.41, 0.20) | − 0.02 (− 0.29, 0.26) | − 0.57 (− 0.92, − 0.21) | − 0.34 (− 0.60, − 0.08) | − 0.18 (− 0.50, 0.13) | |
≥ 3 | Early | 0.14 (− 0.38, 0.67) | − 1.12 (− 1.71, − 0.53) | − 1.11 (− 1.80, − 0.42) | − 0.51 (− 1.10, 0.09) | − 0.01 (− 0.51, 0.50) | − 0.95 (− 1.63, − 0.28) | − 0.07 (− 0.56, 0.41) | − 0.75 (− 1.40, − 0.10) | |
NMS × Period | 0 × | Mid/late | reference | reference | reference | reference | reference | reference | reference | reference |
1 × | Mid/late | 0.03 (− 0.12, 0.18) | 0.27 (0.11, 0.44) | 0.41 (0.22, 0.59) | − 0.01 (− 0.18, 0.16) | 0.21 (0.06, 0.36) | 0.22 (0.02, 0.41) | 0.14 (0.00, 0.28) | 0.15 (− 0.01, 0.32) | |
2 × | Mid/late | − 0.16 (− 0.46, 0.15) | 0.38 (0.03, 0.73) | 0.16 (− 0.23, 0.56) | 0.15 (− 0.18, 0.49) | 0.01 (− 0.29, 0.31) | 0.11 (− 0.29, 0.51) | 0.16 (− 0.12, 0.44) | − 0.19 (− 0.54, 0.17) | |
≥ 3 × | Mid/late | 0.07 (− 0.50, 0.63) | 0.93 (0.26, 1.59) | 0.64 (− 0.11, 1.40) | 0.87 (0.23, 1.51) | − 0.13 (− 0.66, 0.40) | 0.22 (− 0.55, 0.98) | 0.27 (− 0.25, 0.79) | 0.54 (− 0.21, 1.28) |