Fig. 4

Monocyte response to RIG-I/MDA-5 stimulation. A Proportions of monocyte subsets in pregnant (red) and non-pregnant women (blue) with and without Poly(I:C) (HMW) LyoVec™ stimulation. B Heatmap representation of the differences in proportions of monocyte subsets from pregnant (red symbols) and non-pregnant (blue symbols) women following 24 h Poly(I:C) (HMW) LyoVec™ stimulation. Asterisks indicate statistically significant differences between the indicated groups. C-F Frequencies of (C) classical monocytes (CD14^hiCD16⁻), (D) intermediate monocytes (CD14^hiCD16⁺), (E) non-classical monocytes (CD14^loCD16⁺), and (F) CD14^loCD16⁻ monocytes in pregnant (red) and non-pregnant (blue) women following Poly(I:C) (HMW) LyoVec™ stimulation (solid circles) or control (open circles). *p < 0.05; ***p < 0.001. ( +) Stimulated; (-) Control