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Table 4 Meta-analysis of association between high maternal Hb and maternal outcomes

From: Maternal low and high hemoglobin concentrations and associations with adverse maternal and infant health outcomes: an updated global systematic review and meta-analysis

 

Post-Partum

Hemorrhage

OR (95% CI)

Transfusion

OR (95% CI)

Pre-Eclampsia

OR (95% CI)

Gestational

Diabetes

OR (95% CI)

Postpartum

Depression

OR (95% CI)

Prenatal

Depression

OR (95% CI)

Maternal

Mortality

OR (95% CI)

Timing: high maternal Hb (> 130) by timing

     

Preconception

--

--

--

1.24a

(1.11–1.38)

--

--

--

First trimester

--

--

1.61a

(0.92–2.84)

1.73b

(1.10–2.71)

--

--

--

Second trimester

1.01a

(0.95–1.15)

--

1.60a

(1.03–2.48)

--

--

--

--

Third trimester

--

--

1.27a

(1.18–1.36)

--

--

--

--

Cutoff: high maternal Hb at any time during pregnancy by cutoff

≥ 130 g/L

1.00b

(0.95–1.05)

--

1.34

(1.16–1.56)

1.71

(1.19–2.46)

--

--

2.01a

(1.12–3.61)

≥ 140 g/L

1.00b

(0.87–1.14)

--

1.58b

(0.88–2.83)

2.10b

(1.65–2.68)

--

--

2.01a

(1.12–3.61)

≥ 150 g/L

--

--

2.38a

(1.20–4.69)

--

--

--

--

Overall estimate*

≥ 130 g/L

1.00b

(0.95–1.05)

--

1.34

(1.16–1.56)

1.71

(1.19–2.46)

--

--

2.01a

(1.12–3.61)

  1. a based on 1 study
  2. b based on 2 studies
  3. -- no data available
  4. *Overall estimates using Hb concentrations measured at any point during pregnancy
  5. Hb hemoglobin; OR Odds Ratio; CI Confidence Interval