Fig. 6
From: Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents
Effect of p16 deletion on the fertility of mice treated with BUL + CTX. Three months after administering AAs, the females were mated with fertile males. The fertility and litter size in each group. Compared with WT mice: **P < 0.01; ***P < 0.001. Compared with p16 KO mice: ##P < 0.01. WT: WT mice; WT + M: WT mice treated with BUL + CTX; KO mice: untreated p16 KO mice; KO + M: p16 KO mice treated with BUL + CTX.