Fig. 3
From: Loss of p16 does not protect against premature ovarian insufficiency caused by alkylating agents
Effect of p16 deletion on the follicle number at each stage of mice treated with BUL + CTX. Three months after administering AAs, the ovaries were removed. (A) Size of ovaries. n = 6 for each group. (B) Ratio of ovarian weight to body weight. n = 6 for each group. (C) Representative photos of ovarian sections stained with HE, 6 X, n = 3 for each group. (D) Statistical graph of primordial and growing follicle counts. Compared with WT mice: *P < 0.05; **P < 0.01; ***P < 0.001. Compared with p16 KO mice: #P < 0.05; ##P < 0.01; ###P < 0.001. WT: WT mice; WT + M: WT mice treated with BUL + CTX; KO mice: untreated p16 KO mice; KO + M: p16 KO mice treated with BUL + CTX.