Effect modification by developmental stage of embryos on the association between late follicular phase progesterone elevation and live birth in fresh transfers

Table 3 GEE models evaluating the effect of progesterone as categorical variable (interquartile range) on probability of live birth

	Cleavage-Stage Embryo Transferred				Blastocyst-Stage Embryo Transferred
	Live birth	Crude	Model I^a	Model II^b	Live birth	Crude	Model I^a	Model II^b
Progesterone (ng/ml)	N (%)	OR (95% CI) P-value	aOR (95% CI) P- value	aOR (95% CI) P- value	N (%)	OR (95% CI) P- value	aOR (95% CI) P- value	aOR (95%CI) P- value
Q1 (< 0.76)	235 (33.86%)	1.0	1.0	1.0	206 (52.15%)	1.0	1.0	1.0
Q2 (≥ 0.76- < 1.08)	225 (36.12%)	1.10 (0.88, 1.39) 0.393	1.03 (0.82, 1.31) 0.784	1.03 (0.81, 1.31) 0.796	258 (49.90%)	0.91 (0.70, 1.19) 0.501	0.92 (0.71, 1.21) 0.565	0.93 (0.71, 1.21) 0.576
Q3 (≥ 1.08- < 1.45)	171 (33.01%)	0.96 (0.76, 1.22) 0.755	0.92 (0.71, 1.19) 0.510	0.93 (0.72, 1.20) 0.563	289 (49.66%)	0.90 (0.70, 1.17) 0.448	0.87 (0.66, 1.14) 0.311	0.89 (0.68, 1.17) 0.396
Q4 (≥ 1.45)	149 (29.39%)	0.81 (0.63, 1.04) 0.101	0.71 (0.53, 0.94) 0.018	0.72 (0.54, 0.97) 0.030	251 (39.53%)	0.60 (0.46, 0.77) < 0.001	0.54 (0.41, 0.71) < 0.001	0.55 (0.42, 0.73) < 0.001

Generalized estimate equation were used
CI Confidence interval. OR Odd ratio, Q Quartile
^aModel I model adjusted for: female age, gonadotrophin consumption, basal FSH, AFC, E₂ levels on trigger day, oocytes retrieved
^bModel II adjusted for: female age, gonadotrophin consumption, basal FSH, AFC, E₂ levels on trigger day,oocytes retrieved,BMI categories, number of embryo viable and transferred

ISSN: 1471-2393