Hemolytic disease of the fetus and newborn: systematic literature review of the antenatal landscape

Table 1 Patient Characteristics Among 155 HDFN Groups, Including Mothers, Neonates, and Fetuses, From 60 Included Studis

Characteristic	Mean (± SD, Range)	Patient Groups (n)	No. of Studies (References)
Patient group size, n	36.5 (± 68.7, 1.0–334.0)	146^a	60 [2, 22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80]
Gestational age at birth, weeks^b
Mean gestational age	35.1 (± 2.1, 33.0–37.4)	13	9 [23, 26, 28, 47, 53, 63, 65, 70, 72]
Median gestational age	35.4 (± 2.1, 28.0–37.0)	24	12 [31, 35, 42, 45, 51, 59, 60, 62, 63, 75, 76]
Exact gestational age	34.1 (± 2.9, 28.1–38.0)	18	14 [22, 24, 27, 34, 39, 43, 44, 46, 50, 52, 55, 66, 74, 77]
Gestational age at first IUT, weeks
Mean gestational age	26.6 (± 0.1, 26.6–26.7)	4	2 [28, 53]
Median gestational age	25.9 (± 3.4, 21.7–36.3)	27	13 [31, 51, 59,60,61, 63, 64, 69, 73, 75, 79, 80]
Exact gestational age	24.8 (± 3.9, 20.0–30.1)	8	5 [44, 52, 66, 68, 76]

Means, medians, and exact gestational age as reported in each study were used to calculate mean (range)
HDFN Hemolytic disease of the fetus and newborn, IUT Intrauterine transfusion
^aOf the 155 patient groups, 46 (29.7%) groups were single patients from case reports
^bDoes not include 1 study [2] in which the reported percentage of the patient group fell within gestational age ranges (i.e., < 259 days and 259–294 days)

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