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Fig. 3 | BMC Pregnancy and Childbirth

Fig. 3

From: Yolk sac tumor and dysgerminoma in the left gonad following gonadoblastoma in the right gonad in a 46,XY DSD with a novel SRY missense mutation: a case report

Fig. 3

Histopathology of the right gonad. A1 Right primitive ovarian cortex. A2 FOXL2 was weakly expressed in the right primitive ovarian sex cord and stroma. A3 SOX9 was weakly expressed in the right primitive ovarian sex cord and stroma. A4 OCT4-positive primordial germ cells were scattered in the ovarian setting and were positive for both PLAP and CD117 (data not shown). B1 Gonadoblastoma in the right gonad (upright corner showing focal calcification). B2 The sex cord component of gonadoblastoma exhibited strong staining of FOXL2 and SOX9 (B3). B4 Groups of OCT4-positive primordial germ cells crowded adjacent to the sex cord of right gonadoblastoma, which implies clonal expansion. C1 Leydig cells in the right gonadal stroma. C2 The Leydig cells were α-inhibin positive. D1 Seminoma in the early stage. D2 There still remained a small quantity of FOXL2-positive sex cord components in the initiatory seminoma as well as SOX9-positive components (D3). D4 The neoplastic cells of seminoma exhibited CD117 positivity

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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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