Table 1 Maternal characteristics and maternal/infant outcomes for women prescribed antidepressant(s) at any point throughout pregnancy
Cohort (N = 2741) | Bupropion | Citalopram | Escitalopram | Fluoxetine | Sertraline | Overall cohort |
|---|---|---|---|---|---|---|
Drug Frequency (women with drug orders) | 315 (11.5%) | 308 (11.2%) | 470 (17.1%) | 470 (17.1%) | 1443 (52.6%) | 3006 |
Mean maternal age (sd) | 29.8 (5.9) | 29.9 (5.7) | 29.4 (5.5) | 29.0 (6.0) | 28.5 (5.8) | 29.0 (5.8) |
Exposure Profile*,b | ||||||
Throughout pregnancy | 56 (17.8%) | 58 (18.8%) | 86 (18.3%) | 90 (19.1%) | 268 (18.6%) | 558 (18.6%) |
Pre-pregnancy, 1st, & 2nd trimesters | 23 (7.3%) | 21 (6.8%) | 34 (7.2%) | 23 (4.9%) | 103 (7.1%) | 204 (6.8%) |
Pre-pregnancy & 1st trimester | 29 (9.2%) | 36 (11.7%) | 52 (11.1%) | 52 (11.1%) | 114 (7.9%) | 283 (9.4%) |
Pre-pregnancy & 2nd trimester | 15 (4.8%) | 16 (5.2%) | 22 (4.7%) | 24 (5.1%) | 62 (4.3%) | 139 (4.6%) |
2nd & 3rd trimesters | 25 (7.9%) | 23 (7.5%) | 28 (6.0%) | 37 (7.9%) | 95 (6.6%) | 208 (6.9%) |
Pre-pregnancy | 22 (7.0%) | 29 (6.4%) | 30 (3.4%) | 30 (6.4%) | 68 (4.7%) | 179 (5.6%) |
2nd trimester | 54 (17.1%) | 28 (10.4%) | 49 (10.4%) | 66 (14.0%) | 214 (14.8%) | 411 (13.7%) |
3rd trimester | 74 (23.5%) | 67 (21.7%) | 127 (27.0%) | 107 (22.8%) | 393 (27.2%) | 768 (25.5%) |
Race* | ||||||
Asian | 1 (0.3%) | 1 (0.3%) | 1 (0.2%) | 5 (1.1%) | 9 (0.6%) | 17 (0.6%) |
Black | 23 (7.3%) | 27 (8.8%) | 426 (90.6%) | 54 (11.5%) | 171 (11.9%) | 701 (25.6%) |
White | 290 (92.1%) | 274 (89.0%) | 37 (7.9%) | 395 (84.0%) | 1223 (84.8%) | 2219 (80.9%) |
Other/Not Identified | 1 (0.3%) | 1 (0.3%) | 1 (0.2%) | 4 (0.9%) | 8 (0.6%) | 15 (0.5%) |
Ethnicity | ||||||
Non-Hispanic/Latina | 311 (98.7% | 295 (95.8%) | 459 (97.7%) | 449 (95.5%) | 1389 (96.3%) | 2903 (96.2%) |
Hispanic/Latina | 4 (1.3%) | 13 (4.2%) | 11 (2.3%) | 21 (4.5%) | 54 (3.7%) | 103 (3.8%) |
Hospital* | ||||||
Eskenazi | 15 (4.8%) | 19 (6.2%) | 17 (3.6%) | 27 (5.7%) | 116 (8.0%) | 194 (6.4%)a |
IU Health | 300 (95.2%) | 289 (93.8%) | 453 (96.4%) | 443 (94.3%) | 1327 (92.0%) | 2812 (93.5%)a |
Insurance* | ||||||
Commercial | 171 (54.3%) | 140 (45.5%) | 269 (57.2%) | 232 (4.4%) | 678 (47.0%) | 1490 (54.3%) |
Government | 140 (44.4%) | 165 (53.6%) | 196 (41.7%) | 226 (48.1%) | 735 (50.9%) | 1285 (46.9%) |
Self-Pay/None | 4 (1.3%) | 3 (1.0%) | 5 (1.1%) | 12 (2.6%) | 30 (2.1%) | 54 (2.0%) |
Maternal Pregnancy Complications | ||||||
GDM | 35 (11.1%) | 28 (9.1%) | 36 (7.7%) | 43 (9.1%) | 132 (9.1%) | 274 (10.0%) |
HDP | 66 (21.0%) | 50 (16.2%) | 69 (14.7%) | 76 (16.2%) | 228 (15.8%) | 489 (17.8%) |
Infant Outcomes | ||||||
Any Adaptation Syndrome* | 16 (5.1%) | 30 (9.7%) | 47 (10.0%) | 29 (6.2%) | 71 (4.9%) | 193 (7.0%) |
NICU Admission* | 74 (23.5%) | 90 (29.2%) | 147 (31.3%) | 139 (29.6%) | 345 (23.9%) | 795 (29.0%) |
Preterm Birth | 50 (15.9%) | 45 (14.6%) | 72 (15.3%) | 86 (8.3%) | 203 (14.1%) | 456 (16.6%) |
TTN* | 28 (8.9%) | 41 (13.3%) | 60 (12.8%) | 75 (16.0%) | 153 (10.6%) | 357 (13.0%) |