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Table 3 Hierarchical regression models on trimester-based infections in pregnancy and cognitive outcomes (n = 7,410)

From: Maternal infections during pregnancy and child cognitive outcomes

   

Any trimester

1st trimester

2nd trimester

3rd trimester

   

B values ( SE )

Model 1 a

GMDS

Hearing & Speech (verbal)

− 1.55 (.985)

− 0.429 (1.20)

− 1.32 (1.15)

− 0.940 (1.31)

  

Performance

− 0.099 (.778)

0.029 (.943)

− 0.191 (.901)

− 0.177 (1.03)

  

Average

− 0.854 (.543)

− 0.647 (.655)

− 0.623 (.626)

− 0.297 (.717)

 

WPPSI-RUK

Verbal

− 1.45 (.887)

− 0.547 (1.07)

− 0.051 (1.02)

− 2.51 (1.16) *

  

Performance

− 0.438 (.951)

0.647 (1.15)

0.430 (1.10)

− 0.810 (1.25)

  

Fullscale

− 1.07 (.923)

0.037 (1.11)

− 0.061 (1.07)

− 1.95 (1.21)

 

WISC-III

Verbal

− 0.287 (.418)

0.945 (.509)

− 0.120 (.482)

− 1.48 (.562) **

  

Performance

− 0.378 (.427)

0.449 (.517)

− 0.062 (.491)

− 1.49 (.571) **

  

Total

− 0.368 (.412)

0.796 (.501)

− 0.116 (.475)

− 1.64 (.553) **

Model 2 b

GMDS

Hearing & Speech (verbal)

− 0.150 (.148)

− 1.09 (1.38)

− 1.54 (1.33)

− 0.915 (1.55)

  

Performance

− 0.228 (.885)

− 0.169 (1.06)

0.078 (1.02)

− 0.606 (1.19)

  

Average

− 0.637 (.605)

− 0.913 (.729)

− 0.313 (.706)

− 0.530 (.820)

 

WPPSI-RUK

Verbal

− 1.37 (.960)

− 1.14 (1.15)

− 1.42 (1.10)

− 1.75 (1.26)

  

Performance

− 0.508 (1.04)

0.163 (1.25)

− 0.116 (1.20)

− 0.490 (1.38)

  

Fullscale

− 1.04 (.993)

− 0.614 (1.19)

− 0.871 (1.14)

− 1.30 (1.31)

 

WISC-III

Verbal

− 0.063 (.431)

0.317 (.523)

− 0.262 (.498)

− 0.859 (.584)

  

Performance

− 0.192 (.457)

0.151 (.552)

0.228 (.524)

− 1.65 (.615) **

  

Total

− 0.139 (.425)

0.289 (.515)

− 0.070 (.489)

− 1.34 (.574) *

Model 3 c

GMDS

Hearing & Speech (verbal)

− 1.71 (1.22)

− 1.21 (1.44)

− 0.349 (1.39)

− 1.61 (1.64)

  

Performance

− 0.132 (.952)

− 0.077 (1.11)

0.396 (1.08)

− 0.315 (1.27)

  

Average

− 0.612 (.642)

− 0.791 (.756)

0.286 (.734)

− 0.565 (.862)

 

WPPSI-RUK

Verbal

− 1.08 (1.05)

0.852 (1.22)

− 0.983 (1.17)

− 1.64 (1.36)

  

Performance

− 0.167 (1.13)

0.682 (1.32)

− 0.028 (1.27)

− 0.448 (1.47)

  

Fullscale

− 0.692 (1.08)

− 0.150 (1.26)

− 0.540 (1.21)

− 1.24 (1.40)

 

WISC-III

Verbal

0.304 (.467)

0.415 (.557)

− 0.036 (.531)

− 0.603 (.623)

  

Performance

0.172 (.493)

0.259 (.587)

0.496 (.559)

− 1.41 (.655) *

  

Total

0.255 (.459)

0.412 (.548)

0.188 (.522)

− 1.34 (.574)

  1. Linear regression analyses and beta coefficients for trimester-based infections in pregnancy and cognitive outcomes
  2. *p<.05, **p<.01, ***p<.001
  3. a Unadjusted models
  4. b Adjusted for potential confounds of maternal education, maternal age, deprivation, infections in other trimesters
  5. c Adjusted for confounds, and additional covariates of maternal smoking, maternal psychiatric history, gestation, birth weight, and child sex