Table 2 Regimens of fentanyl used in included records by route of administration
Route of Fentanyl | Number of records | Loading Dose (range) | Maintenance Dose |
|---|---|---|---|
Intranasal Fentanyl | 6 | 54–250 µg | The maximum hourly dose was 600 µg, with a maximum total dose of 1200 µg |
Subcutaneous Fentanyl | 5 | 200 µg | After 1 h, additional 50 µg doses could be administered every 15 min, as requested, up to a maximum of 650 µg |
Intravenous Fentanyl | 18 | 25–100 μg | - Same dose every 1–2 h - IV-PCA pump 20 μg, lockout interval 3–6 min. The maximum dose of 240 μg per hour, or four-hour limit of 1000–1500 μg in total - Additional 50 μg was given and repeated every 5–10 min until the patient reported adequate pain relief |
Intrathecal Fentanyl | 21 | 5–75 μg | - If analgesia is inadequate after 15 min, a second dose of same study solution was injected - Other drugs |
Epidural Fentanyl | 9 | 20–125 μg | Other drugs |