Analysis of cellular and cell free mitochondrial DNA content and reactive oxygen species levels in maternal blood during normal pregnancy: a pilot study

Table 1 Clinical characteristics of the study population

Characteristics	Non-Pregnant (NP) (n = 20)	1st trimester (n = 20)	2nd trimester (n = 20)	3rd trimester (n = 20)	P Value*
At enrolment
Age (Years)	27.69 ± 4.85	28.11 ± 3.87	28.5 ± 3.51	31.41 ± 6.38	0.112
BMI (Kg/m³)	23.41 ± 2.50	25.52 ± 3.65	24.88 ± 3.93	24.25 ± 3.69	0.764
SBP/DBP (mmHg)	117.72 ± 9.80/ 78.36 ± 8.22	120.76 ± 11.17/ 75.53 ± 10.29	117.26 ± 11.62/ 70.53 ± 9.92	115.31 ± 10.88/ 71.21 ± 10.15	0.592/ 0.142
Gestational Age (weeks)	N/A	7.72 ± 1.90	16 ± 2.67	32.8 ± 1.30	0.000^#
Haematological changes during pregnancy
Haemoglobin (g/dL)		10.83 2.14	11.81 ± 0.83	11.7 ± 1.19	0.128
Hematocrit (%)		35.56 ± 5.20	37.96 ± 2.35	38.22 ± 5.20	0.258
TLC (×10⁹/L)		9.77 ± 2.62	8.97 ± 2.36	10.39 ± 2.69	0.317
Monocytes (%)		3.30 ± 1.37	2.53 ± 0.99	3.26 ± 1.33	0.178
Lymphocytes (%)		23.30 ± 5.79	21.86 ± 7.44	23.8 ± 12.61	0.839
Eosinophils (%)^a		2.75 ± 2.45 [2 (1.3,3)]	2.13 ± 1.18 [2(1,3)]	2.93 ± 1.57 [2(2,3)]	0.440
Neutrophils (%)		70.84 ± 6.01	73 ± 7.79	70 ± 13.42	0.690
Platelets (×1000/mm³)		258.07 ± 108.63	182.2 ± 57.10	157.43 ± 56.23	0.003^
At delivery
SBP/DBP (mmHg) at delivery		121.1 ± 5.56/ 79.6 ± 5.77	120.8 ± 7.33/ 79.33 ± 7.88	118.36 ± 9.34/ 79.63 ± 8.93	0.557/ 0.994
Gestational Age (weeks) at Delivery		37.31 ± 0.80	37.12 ± 0.79	36.94 ± 1.87	0.809
Baby weight (kg)		2.66 ± 0.84	2.77 ± 0.54	2.76 ± 0.39	0.920

Data are presented in mean ± standard deviation (SD). One-way ANOVA test used to compare the means among four groups followed by multiple comparisons (Bonferroni correction)
*P-value represents post ANOVA significance between groups and within groups
# Multiple comparisons of GA in trimesters: Between 1 and 2 (p < 0.001), 1–3 (p < 0.001) and 2–3 (p < 0.001)
^ Multiple comparisons of platelets in trimesters:: Between 1 and 2 (p = 0.103), 1–3(p = 0.003), 2–3 (p = 0.542)
^aData are also presented as median interquartile range (IQR) within parenthesis compared by Kruskal Wallis H test

ISSN: 1471-2393