Table 4 Comparison of embryo development, pregnancy and neonatal outcomes between SERa + and SERa-oocytes from 545 SER + positive cycles (n = 6,706)

Characteristic

SERa + oocytes (n = 1,715)

SERa- oocytes (n = 4,991)

P-value^*

Percentage, %

25.57 (1,715/6,706)

74.43 (4,991/6,706)

-

2PN fertilization rate, %

61.40 (1,053/1,715)

55.90 (2,792/4,991)

 < 0.001

Poly-pronucleus zygote rate, %

2.10 (36/1,1715)

0.80 (41/4,991)

 < 0.001

Good-quality embryo rate, %

32.30 (311/963)

30.50 (799/2,618)

0.309

Blastocyst formation rate, %

51.30 (241/470)

55.60 (808/1452)

0.098

Only SERa + embryo transfer

Mixed SERa + and SERa- embryo transfer

Only SERa- embryo transfer

No. of transferred embryos, n

148

199

316

-

No. of embryo transfer cycles, n

90

97

185

-

No. of lost follow-up

0

3

2

Implantation rate, %

26.40 (39/148)

23.20 (59/254)

35.40 (112/316)

0.004

Clinical pregnancy rate, %

36.70 (33/90)

43.30 (42/97)

49.70 (92/185)

0.116

EP

1.1(1/90)

1.0(1/97)

1.1 (2/185)

1.000^**

Live birth rate, %

26.70 (24/90)

32.00 (31/97)

40.50 (75/185)

0.061

Spontaneous abortion rate, %

24.20 (8/33)

16.70 (7/42)

14.10 (13/92)

0.411

Premature delivery rate, %

8.30 (2/24)

25.80 (8/31)

9.30 (7/75)

0.073^**

No. of newborns, n

30

42

87

Weeks of gestation, wk

38.14 ± 1.28

37.59 ± 2.11

38.45 ± 1.63

0.912

Weight of singleton births, kg

2.92 ± 0.30

3.06 ± 0.49

3.21 ± 0.71

0.189

Weight of twin births, kg

2.68 ± 0.46

2.39 ± 0.58

2.55 ± 0.24

0.162

Newborn malformation rate, %

3.3 (1/30)

4.80 (2/42)

0.00(0/95)

0.078^**