BMC Pregnancy and Childbirth

Table 2 The diagnostic value and cut-off of IFA for trisomy 21 fetuses; IFA, MNM angle and FMA for trisomy 18 fetuses; MNM angle and FS distance for CLP fetuses

From: Clinical value of fetal facial profile markers during the first trimester

	Trimosy 21	Trimosy 18			CLP
	IFA	IFA	MNM angle	FMA	MNM angle	FS distance
AUC	0.694	0.831	0.81	0.914	0.964	0.89
95% CI	0.536 ~ 0.852	0.668 ~ 0.993	0.659 ~ 0.961	0.827 ~ 1	0.926 ~ 1	0.794 ~ 0.987
Sensitivity	0.643	0.704	0.933	0.85	0.912	0.868
Specificity	0.714	0.857	0.571	0.857	0.9	0.8
Cut-off	76.34°	75.37°	7.24°	67.96°	6.83°	0.35 mm
p value	0.013^a	0.003^a	0.005^a	p < 0.001^a	p < 0.001^a	p < 0.001^a

AUC area under curve, CI confidence interval, CLP cleft lip and palate, IFA inferior facial angle, MNM angle maxilla-nasion-mandible angle, FMA facial maxillary angle, FS distance frontal space distance
^aDenotes significant values if p < 0.05

Back to article page

ISSN: 1471-2393

Contact us

Submission enquiries: bmcpregnancyandchildbirth@biomedcentral.com
General enquiries: ORSupport@springernature.com