Table 3 Stratified sibling cohort analysis of association between antenatal DEP-ANX and GDM. RDs and ORs represent the risk or log likelihood of GDM among those with antenatal DEP-ANX compared to those without
Sample of interest | Cases of GDM, N (%) | Base model | Adjusted OR (95% CI) a | ||||
|---|---|---|---|---|---|---|---|
DEP-ANX history | Number of deliveries | Unexposed | Exposed | Absolute RD, % (95% CI) a | Unadjusted OR (95% CI) a | Model 1 b | Model 2 c |
Base analysis | |||||||
 Full cohort | 314,615 | 20,402 (8.0) | 5494 (9.2) | 1.21 (0.96 – 1.47) | 1.17 (1.13 – 1.20) | 1.17 (1.14 – 1.22) | 1.14 (1.10 – 1.18) |
 No history | 136,416 | 9353 (7.7) | 1350 (9.2) | 1.54 (1.04 – 2.03) | 1.22 (1.15 – 1.30) | 1.24 (1.17 – 1.32) | 1.23 (1.16 – 1.31) |
 Any history | 178,199 | 11,049 (8.3) | 4144 (9.2) | 0.92 (0.61 – 1.22) | 1.12 (1.08 – 1.16) | 1.14 (1.10 – 1.19) | 1.11 (1.07 – 1.15) |
Unmatched sibling analysis | |||||||
 Full cohort | 173,819 | 9842 (6.9) | 2507 (8.0) | 1.13 (0.80 – 1.46) | 1.18 (1.12 – 1.24) | 1.20 (1.14 – 1.26) | 1.15 (1.09 – 1.21) |
 No history | 72,825 | 4078 (6.2) | 536 (7.5) | 1.31 (0.67 – 1.95) | 1.23 (1.12 – 1.35) | 1.24 (1.17 – 1.32) | 1.23 (1.16 – 1.31) |
 Any history | 100,994 | 5764 (7.5) | 1971 (8.2) | 0.69 (0.30 – 1.09) | 1.10 (1.04 – 1.16) | 1.13 (1.07 – 1.20) | 1.09 (1.03 – 1.16) |
Matched sibling analysis | |||||||
 Full cohort | 14,633 | 5548 (47.3) | 1415 (48.8) | 1.51 (-0.52 – 3.54) | 1.05 (0.96 – 1.15) | 1.08 (0.97 – 1.19) | 1.07 (0.96 – 1.18) |
 No history | 4726 | 2116 (46.7) | 136 (68.3) | 21.60 (14.98 – 28.22) | 2.27 (1.68 – 3.07) | 1.18 (0.86 – 1.62) | 1.18 (0.86 – 1.63) |
 Any history | 7850 | 2785 (47.8) | 977 (48.3) | 0.56 (-1.96 – 3.09) | 1.01 (0.90 – 1.13) | 1.04 (0.91 – 1.18) | 1.02 (0.90 – 1.16) |