Preconception mental health and the relationship between antenatal depression or anxiety and gestational diabetes mellitus: a population-based cohort study

Table 2 Association between antenatal DEP-ANX and GDM across preconception DEP-ANX persistence strata. RDs and ORs represent the log likelihood of GDM among those with antenatal DEP-ANX compared to those without

Sample of interest		Frequency of GDM, N (%)		Base model		Adjusted OR (95% CI) ^a
DEP-ANX history	Number of deliveries	Unexposed	Exposed	Absolute RD, % (95% CI) ^a	Unadjusted OR (95% CI) ^a	Model 1 ^b	Model 2 ^c
Base analysis
Full cohort	228,144	15,102 (8.2)	4180 (9.6)	1.39 (1.08 – 1.69)	1.19 (1.15 – 1.23)	1.20 (1.15 – 1.24)	1.16 (1.11 – 1.20)
Stratified analysis
No history	91,109	6279 (7.7)	898 (9.3)	1.61 (1.00 – 2.22)	1.23 (1.14 – 1.32)	1.26 (1.17 – 1.36)	1.25 (1.16 – 1.35)
Episodic	62,994	4266 (8.1)	927 (8.9)	0.74 (0.14 – 1.33)	1.10 (1.02 – 1.18)	1.14 (1.06 – 1.23)	1.13 (1.05 – 1.22)
Chronic, discontinuous	7470	506 (9.4)	227 (10.9)	1.45 (-0.10 – 2.99)	1.17 (0.99 – 1.38)	1.21 (1.02 – 1.43)	1.17 (0.98 – 1.39)
Chronic, Continuous	66,571	4051 (9.0)	2128 (9.9)	0.93 (0.45 – 1.41)	1.11 (1.05 – 1.18)	1.13 (1.07 – 1.19)	1.10 (1.04 – 1.17)

Abbreviations: DEP-ANX depression and/or anxiety, GDM gestational diabetes mellitus. RD risk difference, CI confidence interval, OR odds ratio
^a Reference group: no exposure to antenatal DEP-ANX
^b Adjusted for year of birth, birth parent age category, neighborhood-based income quintile, marital status, and number of living children
^c Adjusted for items in Model 1 and preconception body mass index (BMI), pregnancy-induced hypertension (PIH), non-pregnancy induced hypertension (non-PIH), antenatal hospitalization, and intrauterine growth restriction (IUGR)

ISSN: 1471-2393