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Table 1 Comparison of socio-demographic and clinical characteristics among individuals with and without antenatal DEP-ANX

From: Preconception mental health and the relationship between antenatal depression or anxiety and gestational diabetes mellitus: a population-based cohort study

 

Antenatal DEP-ANX

No N = 184,480

Yes N = 43,664

Standardized difference a

Birth parent socio-demographic factors

Birth parent age group, N (%)

  

0.060

 < 20 years

6136 (3.3)

1610 (3.7)

 

 20 – 24 years

23,958 (13.0)

5797 (13.3)

 

 25 – 29 years

48,480 (26.3)

11,021 (25.2)

 

 30 – 34 years

62,232 (33.7)

14,104 (32.3)

 

35 – 39 years

35,735 (19.4)

8858 (20.3)

 

 ≥ 40 years

7939 (4.3)

2274 (5.2)

 

Neighborhood-based income quintile, N (%)

  

0.024

1

37,931 (20.6)

9215 (21.1)

 

2

38,793 (21.0)

9204 (21.1)

 

3

38,433 (20.8)

9140 (20.9)

 

4

38,792 (21.0)

9238 (21.2)

 

5

30,531 (16.5)

6867 (15.7)

 

Marital status, N (%)

  

0.145 *

Divorced

2760 (1.5)

926 (2.1)

 

Married

128,164 (69.5)

27,473 (62.9)

 

Never married

36,243 (19.6)

10,321 (23.6)

 

Other

14,493 (7.9)

3925 (9.0)

 

Single

2820 (1.5)

1019 (2.3)

 

Coparent status

   

Coparent listed, N (%)

178,246 (96.6)

41,219 (94.4)

0.107 *

Coparent age (years), Mean (SD)

33.5 (6.3)

33.7 (6.6)

0.036

Number of living children, N (%)

  

0.086

0

80,664 (43.7)

20,789 (47.6)

 

1

69,341 (37.6)

14,748 (33.8)

 

2

23,917 (13.0)

5627 (12.9)

 

3

6987 (3.8)

1692 (3.9)

 

4 or more

3571 (1.9)

808 (1.9)

 

Pregnancy characteristics and risk factors

Year of birth, N (%)

  

0.035

  < 2008

46,504 (25.2)

11,452 (26.2)

 

 2008 – 2010

67,685 (36.7)

16,298 (37.3)

 

  > 2010

70,291 (38.1)

15,914 (36.4)

 

Smoking status during pregnancy, N (%)

  

0.127 *

No history of smoking

152,610 (82.7)

33,947 (77.7)

 

Continued during pregnancy

15,947 (8.6)

5104 (11.7)

 

Discontinued during pregnancy

15,923 (8.6)

4613 (10.6)

 

History of premature birth, N (%)

7641 (4.1)

1983 (4.5)

0.020

Nulliparous, N (%)

79,464 (43.1)

20,423 (46.8)

0.074

Preconception BMI, N (%) b

  

0.066

< 18.5 (underweight)

6193 (3.4)

1523 (3.5)

 

18.5 – 24.99 (normal)

77,149 (41.8)

18,000 (41.2)

 

25.0 – 29.99 (overweight)

28,378 (15.4)

7166 (16.4)

 

≥ 30 (obese)

18,167 (9.8)

4948 (11.3)

 

Missing

54,593 (29.6)

12,027 (27.5)

 

Gestational diabetes, N (%)

15,102 (8.2)

4180 (9.6)

0.049

Insulin-dependent

4155 (2.3)

1232 (2.8)

0.036

Non-insulin dependent

10,947 (5.9)

2948 (6.8)

0.034

Hypertension, N (%)

 Pregnancy-induced

9167 (5.0)

2560 (5.9)

0.040

 Other c

6017 (3.3)

1607 (3.7)

0.023

Prenatal care, N (%)

  ≥ 10 prenatal visits

58,805 (31.9)

16,148 (37.0)

0.108 *

 Prior hospital admission

16,573 (9.0)

5361 (12.3)

0.107 *

IUGR, N (%)

3047 (1.7)

815 (1.9)

0.016

Nature of labor, N (%)

 Vaginal delivery

129,673 (70.3)

29,538 (67.6)

0.057

 Induced labor

37,292 (20.2)

9651 (22.1)

0.046

 Midwifery care

27,286 (14.8)

4521 (10.4)

0.134 *

Postpartum and neonatal characteristics

Infant sex, N (%)

89,827 (48.7)

21,095 (48.3)

0.008

Gestational age (weeks), mean (SD)

38.7 (1.9)

38.6 (2.0)

0.067

Size at birth d

 Small-for-gestational-age, N (%) e

15,701 (8.5)

3858 (8.8)

0.012

 Large-for-gestational-age, N (%) f

19,883 (10.8)

4725 (10.8)

0.001

Admission to NICU, N (%)

4454 (2.4)

1317 (3.0)

0.037

Preterm birth, N (%)

14,404 (7.8)

3978 (9.1)

0.047

  1. Abbreviations: DEP-ANX depression and/or anxiety, BMI body mass index, IUGR intrauterine growth restriction, NICU neonatal intensive care unit
  2. a A standardized difference of 0.1 or greater was deemed meaningful and designated with a (*)
  3. b Equal to weight (kilograms) divided by height (meters) squared
  4. c Comprised of preexisting hypertension, high blood pressure, hypertensive kidney disease, proteinuria, HELLP (Hemolysis, Elevated Liver enzymes, and Low Platelets) syndrome, and other hypertensive disorders
  5. d Percentiles determined based on birth weights within gestational age (GA) and infant sex subgroups
  6. e Below the 10th percentile of weight for final GA and sex
  7. f Above the 90th percentile of weight for final GA and sex