Table 2 Frequency of endpoints by trimester of diagnosis
| Â | Study cohort, pregnancies (n, 1092), exposure: 2nd and/or 3rd trimester, n (%) | Comparison cohort, pregnancies (n, 1154), exposure: 1st trimester, n (%) | Risk ratio, RR (95% CI) |
|---|---|---|---|
Constriction of ductus arteriosus | 5/1092 (0.5) | 0/1154 (0.0) | Â |
  •2nd trimester | 1/904 (0.1) | 0/1154 (0.0) |  |
  •3rd trimester | 2/1092 (0.2) | 0/1154 (0.0) |  |
  •Not clearly assignable to trimester | 2/1092 (0.2) | 0/1154 (0.0) |  |
Oligohydramnios | 41/1092 (3.8) | 29/1154 (2.5) | 1.5 (0.9–2.4) |
  •2nd trimester | 8/904 (0.9) | 2/1154 (0.2) | 5.1 (1.1–24.0) |
  •3rd trimester | 23/1092 (2.1) | 20/1154 (1.7) |  |
  •Not clearly assignable to trimester | 10/1092 (0.9) | 7/1154 (0.6) |  |
Late SAB/fetal death | 14/1092 (1.3) | 17/1154 (1.5) | Â |
  •2nd trimester | 11/904 (1.2) | 12/1154 (1.0) |  |
  •3rd trimester | 3/1092 (0.3) | 5/1154 (0.4) |  |
ETOP (after 1st trimester) | 10/1092 (0.9) | 16/1154 (1.4) | Â |
| Â | Live-born infants (n, 1098) | Live-born infants (n, 1133) | Â |
Patent ductus arteriosus | 15/1098 (1.4) | 10/1133 (0.9) | 1.6 (0.7–3.4) |
  •term-born (≥ 37 + 0 GW) | 4/933a (0.4) | 5/1010a (0.5) | 0.9 (0.2–3.2) |
  •preterm-born (<  37 + 0 GW) | 11/162a (6.8) | 5/117a (4.3) | 1.6 (0.6–4.5) |
PPHT and other cardiac anomaliesb | 5/1098 (0.5) | 2/1133 (0.2) | 2.6 (0.5–13.3) |
Renal disorder | 1/1098 (0.1) | 1/1133 (0.1) | 1.0 (0.1–16.5) |