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Table 3 Reference intervals for normal pregnant women in different stages of pregnancies

From: Consecutive reference intervals for biochemical indices related to serum lipid levels and renal function during normal pregnancy

Analyte

Established interval

Gestational age

 ≤ 8 W

8 W+1-12 W

12 W+1-16 W

16 W+1-20 W

20 W+1-24 W

24 W+1-28 W

28 W+1-32 W

32 W+1-36 W

36 W+1-40 W

TC (mmol/L)

 Mean

3.36–5.69

4.02

4.19

4.67

5.12

5.66

6.03

6.33

6.38

6.60

 Lower limit

2.82 (2.68–3.01)

3.10 (2.88–3.25)

3.41 (3.28–3.62)

3.82 (3.46–4.05)

3.97 (3.15–4.25)

4.28 (3.78–4.56)

4.55 (4.14–4.77)

4.57 (4.46–4.66)

4.58 (4.28–4.98)

 Upper limit

5.25 (5.02–6.62)

5.30 (5.15–5.77)

6.08 (5.71–6.32)

6.86 (6.49–7.02)

7.40 (7.11–7.61)

8.15 (7.62–8.43)

8.10 (7.91–8.48)

8.42 (8.00–8.90)

9.23 (8.25–10.97)

 n%

 

14.2

5.8

4.2

20.0

45.0

60.0

70.8

69.2

75.8

TG (mmol/L)

 Median

0.40–1.69

0.72

1.06

1.43

1.73

2.02

2.28

2.63

2.98

3.23

 Lower limit

0.34 (0.33–0.40)

0.57 (0.44–0.64)

0.81 (0.75–0.88)

0.82 (0.68–1.03)

1.00 (0.94–1.10)

1.23 (1.15–1.32)

1.35 (1.29–1.58)

1.67 (1.59–1.90)

2.02 (1.56–2.14)

 Upper limit

2.16 (1.62–2.33)

2.30 (1.96–3.37)

3.08 (2.41–3.31)

3.99 (3.01–5.16)

4.28 (3.13–5.85)

4.86 (4.13–5.27)

5.76 (4.90–8.03)

6.46 (5.73–6.97)

6.27 (6.01–7.69)

 n%

 

6.7

5.0

30.0

50.8

63.3

79.2

88.3

95.0

97.5

HDL-C (mmol/L)

 Mean

1.00–2.10

1.45

1.63

1.81

1.93

2.04

2.10

2.04

1.98

2.03

 Lower limit

0.91 (0.73–0.98)

1.04 (0.86–1.10)

1.15 (0.94–1.26)

1.32 (1.14–1.35)

1.26 (1.19–1.35)

1.37 (1.06–1.49)

1.29 (1.08–1.51)

1.23 (0.85–1.36)

1.19 (0.94–1.37)

 Upper limit

2.28 (1.97–2.44)

2.38 (2.19–2.44)

2.56 (2.48–2.63)

2.62 (2.49–2.78)

2.64 (2.59–2.83)

2.68 (2.56–3.32)

2.69 (2.59–2.95)

2.71 (2.56–3.45)

2.95 (2.55–3.98)

 n%

 

5.8

6.7

15.0

39.0

41.7

52.5

43.3

35.0

37.5

LDL-C (mmol/L)

 Median

 < 3.37

2.17

2.15

2.41

2.62

3.00

3.31

3.63

3.59

3.59

 Upper limit

3.17 (3.03–4.41)

3.03 (2.74–3.12)

3.19 (3.13–3.63)

3.89 (3.61–4.23)

4.40 (4.10–4.49)

4.94 (4.42–5.40)

5.00 (4.87–5.18)

5.16 (4.85–5.56)

5.56 (5.08–6.05)

 n%

 

0.0

0.0

0.0

9.2

28.3

40.8

59.2

54.2

55.8

Apo-A1 ( g/L)

 Median

1.20–1.90

1.52

1.78

2.03

2.14

2.23

2.24

2.25

2.22

2.28

 Lower limit

1.00 (0.93–1.15)

1.28 (1.08–1.37)

1.38 (1.24–1.55)

1.60 (1.32–1.68)

1.61 (1.40–1.75)

1.73 (1.39–1.80)

1.68 (1.53–1.74)

1.63 (1.28–1.83)

1.82 (1.36–1.85)

 Upper limit

2.11 (1.87–2.24)

2.30 (2.12–2.33)

2.42 (2.37–2.49)

2.43 (2.39–2.62)

2.58 (2.55–2.84)

2.87 (2.71–2.99)

2.77 (2.61–3.50)

2.91 (2.69–3.10)

2.85 (2.64–3.00)

 n%

 

3.3

31.7

65.0

80.8

87.5

90.0

90.0

90.0

91.7

Apo-B ( g/L)

 Median

0.75–1.50

0.66

0.68

0.78

0.88

0.99

1.08

1.19

1.20

1.22

 Lower limit

0.40 (0.39–0.46)

0.44 (0.32–0.46)

0.48 (0.40–0.54)

0.53 (0.43–0.58)

0.61 (0.45–0.69)

0.64 (0.56–0.73)

0.74 (0.69–0.79)

0.78 (0.69–0.83)

0.78 (0.71–0.83)

 Upper limit

1.16 (0.99–1.41)

1.00 (0.92–1.22)

1.12 (1.08–1.32)

1.37 (1.29–1.42)

1.51 (1.39–1.61)

1.58 (1.52–1.81)

1.66 (1.64–1.75)

1.71 (1.67–1.98)

1.94 (1.63–2.22)

 n%

 

67.5

63.3

37.5

25.0

9.2

10.0

13.3

14.2

20.0

Urea (mmol/L)

 Median

2.60–7.50

2.99

2.53

2.50

2.51

2.60

2.67

2.66

2.68

2.94

 Lower limit

1.97 (1.79–2.08)

1.75 (0.60–1.81)

1.57 (1.31–1.75)

1.51 (1.18–1.63)

1.60 (1.34–1.89)

1.71 (1.51–1.97)

1.68 (1.59–1.79)

1.50 (1.35–1.77)

1.91 (1.89–2.04)

 Upper limit

4.73 (4.49–6.61)

3.83 (3.54–5.05)

4.11 (3.67–4.56)

4.04 (3.37–4.85)

3.87 (3.65–4.20)

4.55 (3.82–4.72)

3.98 (3.82–4.07)

4.29 (3.88–5.04)

4.77 (4.05–5.34)

 n%

 

25.0

52.5

58.3

56.7

48.3

39.2

43.3

43.3

29.2

Crea (μmol/L)

 Median

41.0–73.0

46.4

41.9

40.4

40.2

39.9

40.5

41.4

42.4

45.2

 Lower limit

37.1 (30.8–38.1)

33.2 (31.8–34.9)

32.1 (28.4–33.0)

30.0 (28.3–31.8)

28.3 (26.4–32.6)

30.3 (26.9–32.1)

28.1 (27.3–32.1)

29.3 (27.4–33.6)

34.4 (33.4–35.3)

 Upper limit

62.4 (58.8–64.0)

54.9 (52.8–57.0)

52.7 (50.4–56.0)

51.9 (50.2–54.8)

52.5 (49.2–64.9)

55.8 (52.7–63.2)

55.4 (52.5–61.7)

55.6 (52.7–63.5)

59.8 (57.4–63.7)

 n%

 

10.8

40.8

52.5

56.7

59.2

51.7

46.7

40.8

20.8

Cys-C ( mg/L)

 Median

0.59–1.03

0.75

0.70

0.71

0.76

0.79

0.86

0.94

1.08

1.25

 Lower limit

0.63 (0.57–0.64)

0.55 (049–0.57)

0.57 (0.51–0.61)

0.59 (0.56–0.62)

0.62 (0.58–0.64)

0.64 (0.60–0.67)

0.73 (0.69–0.75)

0.82 (0.77–0.85)

0.96 (0.88–0.97)

 Upper limit

0.95 (0.91–0.97)

0.86 (0.83–0.96)

0.88 (0.85–1.05)

0.95 (0.92–0.99)

1.03 (0.98–1.10)

1.07 (1.05–1.14)

1.33 (1.23–1.41)

1.68 (1.51–1.76)

1.72 (1.68–1.96)

n%

 

0.0

5.8

0.8

0.0

0.0

5.0

23.3

60.0

85.8

UA (μmol/L)

 Median

150–350

225

201

207

215

219

227

235

256

281

 Lower limit

145 (98–157)

133 (105–143)

141 (111–150)

141 (115–154)

150 (98–162)

142 (106–162)

145 (108–165)

161 (146–175)

167 (128–188)

 Upper limit

326 (320–343)

299 (277–315)

308 (273–327)

325 (306–375)

326 (299–338)

318 (309–408)

331 (321–363)

355 (343–412)

464 (406–525)

 n%

 

2.5

5.8

3.3

2.5

0.0

1.7

3.3

0.8

9.2

eGFR [mL/(min·1.73m2)]

 Median

80–120

127

132

134

134

135

134

133

132

129

 Lower limit

114 (112–116)

120 (119–122)

122 (117–124)

121 (119–123)

119 (112–124)

117 (115–121)

118 (117–121)

117 (115–120)

117 (109–118)

 Upper limit

142 (139–148)

144 (142–148)

147 (143–152)

148 (145–151)

153 (147–156)

152 (143–155)

154 (146–157)

149 (142–154)

144 (141–146)

 n%

 

83.3

95.8

95.0

95.8

95.0

94.2

96.2

93.3

90.0

  1. Apo-A1 Apolipoprotein-A1, Apo-B Apolipoprotein-B, Crea Creatinine, Cys-C Cystatin C, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, TC Total cholesterol, TG Triglycerides, UA Uric acid, eGFR Estimated glomerular filtration rate, W Week
  2. The 90% confidence intervals for the lower and upper limits are given in parentheses;
  3. n%: proportions of pregnant women whose parameters values were outside the range of established reference intervals for healthy adult females