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Table 2 Results of serum lipid level and renal function indexes in normal pregnant women during different stages of pregnancies

From: Consecutive reference intervals for biochemical indices related to serum lipid levels and renal function during normal pregnancy

Index

pre-pregnancy

Gestational age

 ≤ 8 W

8 W+1-12 W

12 W+1-16 W

16 W+1-20 W

20 W+1-24 W

24 W+1-28 W

28 W+1-32 W

32 W+1-36 W

36 W+1-40 W

BMI (kg/m2)a

21.14 ± 2.63

21.92 ± 2.99

21.71 ± 4.20

21.95 ± 4.30

22.10 ± 5.14*

23.34 ± 4.37*

24.27 ± 4.46*

25.16 ± 4.57*

26.03 ± 4.65*

26.70 ± 4.78*

TC (mmol/L)b

4.42 (4.17, 4.74)

3.92 (3.63, 4.35)*

4.23 (3.79, 4.62)

4.69 (4.24, 5.10)

5.06 (4.54, 5.68)*

5.62 (5.06, 6.25)*

6.04 (5.32, 6.60)*

6.39 (5.61, 7.06)*

6.45 (5.55, 7.00)*

6.50 (5.73, 7.44)*

TG (mmol/L)b

0.86 (0.65, 1.22)

0.72 (0.56, 0.87)

1.06 (0.82, 1.35)

1.43 (1.11, 1.77)*

1.73 (1.32, 2.11)*

2.02 (1.56, 2.41)*

2.28 (1.85, 2.75)*

2.63 (2.04, 3.19)*

2.98 (2.54, 3.54)*

3.23 (2.70, 4.02)*

HDL-C(mmol/L)b

1.43 (1.24, 1.61)

1.42 (1.23, 1.66)

1.60 (1.44, 1.84)*

1.79 (1.57, 2.04)*

1.92 (1.71, 2.17)*

2.06 (1.75, 2.32)*

2.16 (1.90, 2.37)*

2.05 (1.79, 2.32)*

1.96 (1.73, 2.29)*

2.02 (1.74, 2.32)*

LDL-C(mmol/L)b

2.55 (2.33, 2.82)

2.17 (1.83, 2.58)*

2.15 (1.86, 2.49)*

2.41 (2.06, 2.76)

2.62 (2.24, 3.06)

3.00 (2.59, 3.60)*

3.31 (2.82, 3.78)*

3.63 (3.01, 4.18)*

3.59 (3.03, 4.26)*

3.59 (2.95, 4.31)*

Apo-A1 (g/L)b

1.48 (1.36, 1.60)

1.52 (1.37, 1.67)

1.78 (1.58, 1.97)*

2.03 (1.84, 2.15)*

2.14 (1.97, 2.26)*

2.23 (2.03, 2.34)*

2.24 (2.13, 2.36)*

2.25 (2.13, 2.38)*

2.22 (2.09,2.34)*

2.28 (2.12, 2.40)*

Apo-B (g/L)b

0.86 (0.79, 0.93)

0.66 (0.57, 0.78)*

0.68 (0.57, 0.79)*

0.78 (0.70, 0.92)

0.88 (0.74, 1.03)

0.99 (0.86, 1.17)*

1.08 (0.96, 1.27)*

1.19 (1.01, 1.41)*

1.20 (1.04, 1.42)*

1.22 (1.05, 1.48)*

Urea (mmol/L)b

4.19 (3.64, 5.06)

2.99 (2.58, 3.51)*

2.53 (2.27, 2.92)*

2.50 (2.13, 2.92)*

2.51 (2.14, 2.90)*

2.60 (2.23, 3.00)*

2.67 (2.36, 3.04)*

2.66 (2.30, 3.14)*

2.68 (2.28, 3.06)*

2.94 (2.47, 3.46)*

Crea (μmol/L)b

57.4 (53.7, 61.1)

46.4 (43.0, 51.9)*

41.9 (39.5, 46.1)*

40.4 (38.1, 44.5)*

40.2 (37.3, 44.1)*

39.9 (37.2, 43.5)*

40.5 (37.7, 43.7)*

41.4 (38.3, 45.7)*

42.4 (38.4, 46.1)*

45.2 (41.7, 50.1)*

Cys-C (mg/L)b

0.73 (0.68, 0.79)

0.75 (0.71, 0.81)

0.70 (0.64, 0.77)*

0.71 (0.66, 0.78)

0.76 (0.69, 0.81)

0.79 (0.73,0.88)*

0.86 (0.76, 0.93)*

0.94 (0.86, 1.04)*

1.08 (0.97, 1.23)*

1.25 (1.14, 1.39)*

UA (μmol/L)b

278 (242, 313)

225 (193, 259)*

201 (174, 231)*

207 (193, 235)*

215 (187, 237)*

219 (193, 255)*

227 (201, 252)*

235 (208, 270)*

256 (223, 288)*

281 (245. 321)

eGFR [mL/(min·1.73m2)]b

119 (116, 122)

127 (123, 131)*

132 (128, 136)*

134 (129, 137)*

134 (130, 137)*

135 (131, 138)*

134 (129, 138)*

133 (129, 137)*

132 (127, 137)*

129 (124, 133)*

  1. Apo-A1 Apolipoprotein-A1, Apo-B Apolipoprotein-B, BMI Body mass index, Crea Creatinine, Cys-C Cystatin C, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, TC Total cholesterol, TG Triglycerides, UA Uric acid, eGFR Estimated glomerular filtration rate, W Week
  2. Before and during pregnancy, the datas of BMI, TC, HDL-C followed a normal distribution and were expressed as mean ± standard deviation; TG, LDL-C, Apo-A1, Apo-B, Urea, Crea, Cys-C, UA did not follow a normal distribution and were expressed as median (interquartile range)
  3. aComparisons using the one-way ANOVA followed by Bonferroni adjustment
  4. bComparisons using the Kruskal–Wallis test followed by the Dunn post-test
  5. *P < 0.05 was considered statistically significant, p-Value that indicates statistical comparisons for this study between the results for pre-pregnancy and each different stages of pregnancies
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BMC Pregnancy and Childbirth

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