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Table 2 Relationship between VitD intake and obstetric outcomes among women who conceived without ART

From: Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study

 

Quintile for VitD

 

Q1 (low)

Q2

Q3

Q4

Q5 (high)

p-valuea

n = 17,687

n = 17,407

n = 17,254

n = 17,532

n = 17,415

VitD intake before pregnancy, μg/day, median (IQR)

1.4 (0.8–1.8)

3.0 (2.6–3.3)

4.3 (4.0–4.7)

6.0 (5.5–6.7)

10.2 (8.7–12.8)

 

PTB at < 37 weeks

 Number, n

729

784

724

704

749

 

 Occurrence, %

4.1

4.5

4.2

4.0

4.3

0.812

 aOR (95% CI)

0.97 (0.89–1.09)

1.08 (0.97–1.12)

1 (Ref)

0.95 (0.85–1.05)

1.02 (0.92–1.13)

 

PTB at < 34 weeks

 Number, n

145

157

138

119

145

 

 Occurrence, %

0.8

0.9

0.8

0.7

0.8

0.361

 aOR (95% CI)

1.02 (0.81–1.30)

1.14 (0.90–1.43)

1 (Ref)

0.85 (0.66–1.08)

1.05 (0.83–1.33)

 

LBW < 2500 g

 Number, n

1371

1397

1264

1256

1352

 

 Occurrence, %

7.8

8.0

7.3

7.2

7.8

0.198

 aOR (95% CI)

1.00 (0.92–1.09)

1.09 (1.01–1.18)

1 (Ref)

0.99 (0.91–1.07)

1.09 (1.00–1.18)

 

LBW < 1500 g

 Number, n

79

91

68

66

73

 

 Occurrence, %

0.4

0.5

0.4

0.4

0.4

0.203

 aOR (95% CI)

1.17 (0.84–1.63)

1.35 (0.98–1.87)

1 (Ref)

0.97 (0.69–1.37)

1.12 (0.80–1.56)

 

SGA

 Number, n

868

860

777

851

963

 

 Occurrence, %

4.9

5.0

4.5

4.9

5.6

0.025

 aOR (95% CI)

1.06 (0.96–1.17)

1.09 (0.99–1.21)

1 (Ref)

1.10 (0.99–1.22)

1.26 (1.14–1.39)

 

HDP

 Number, n

415

394

357

377

364

 

 Occurrence, %

2.4

2.3

2.1

2.2

2.1

0.076

 aOR (95% CI)

1.05 (0.91–1.22)

1.06 (0.92–1.23)

1 (Ref)

1.04 (0.90–1.21)

1.00 (0.86–1.16)

 
  1. VitD Vitamin D, ART Assisted reproductive technology, IQR Interquartile range, PTB Preterm birth, aOR Adjusted odds ratio, CI Confidence interval, Ref Reference, LBW Low-birth weight infant, SGA Small for gestational age, HDP Hypertensive disorder of pregnancy
  2. aOR was calculated by logistic regression analysis, using maternal age (20–29 years old as the reference), body mass index before pregnancy, maternal smoking status, maternal education, endometriosis, parity, and daily calorie intake
  3. a Mantel–Haenszel’s chi-square test for linear trends