Analysis of the risk of complications during pregnancy in pregnant women with assisted reproductive technology: a retrospective study using registry linkage from 2013 to 2018 in Shanghai, China

Table 4 The risk of hypertensive disorders in ART pregnancies ^a

Variable	Risk of PIH^b (Crude OR) ^c			Risk of PIH (Adjusted OR) ^d
Variable	OR	95% CI	P value	OR	95% CI	P value
Patient factors
Patient age (years)	1.023	1.005–1.042	0.011	1.038	1.018–1.058	< 0.001
Primiparous	1.060	0.789–1.423	0.701	1.221	0.903–1.651	0.194
No. of cycles
1–2	ref	/	/	ref	/	/
≥3	1.215	0.963–1.534	0.100	1.116	0.877–1.422	0.372
Male factor only	0.675	0.545–0.837	< 0.001	0.714	0.558–0.913	0.007
Endometriosis diagnosis	0.640	0.344–1.191	0.159	0.681	0.361–1.287	0.237
Ovulatory disorder (mainly PCOS)	1.330	0.989–1.788	0.059	1.206	0.879–1.653	0.239
Tubal diagnosis	0.969	0.850–1.105	0.640	0.968	0.832–1.127	0.677
Treatment factors
Frozen embryo transfer	1.586	1.362–1.848	< 0.001	1.528	1.303–1.793	< 0.001
ICSI	1.048	0.915–1.200	0.499	1.141	0.986–1.321	0.077
Period of transferred embryos
Day 2–3	ref	/	/	ref	/	/
Day 4	0.941	0.400–2.212	0.889	0.940	0.731–1.209	0.631
Day 5–6	1.190	0.936–1.513	0.154	1.111	0.452–2.727	0.819
No. of embryos transferred
1	0.813	0.591–1.120	0.206	1.407	0.875–2.263	0.159
2	ref	/	/	ref	/	/
3	0.771	0.483–1.230	0.274	1.532	0.861–2.724	0.147
Multiple pregnancies	2.400	2.096–2.749	< 0.001	2.536	2.204–2.917	< 0.001

^a. The research objects in this table are all ART patients, n = 8102
^b. PIH, pregnancy-induced hypertention
^c. All odds ratio are for the risk of PIH from logistic regression
^d. Adjusted for patient factors (age, parity, number of cycles and infertility factors), treatment factors (frozen embryo transfer, ICSI, period of transferred embryos and number of embryos transferred), andmultiple pregnancies

ISSN: 1471-2393