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Table 7 Chronotherapeutic interventions

From: A scoping review of non-pharmacological perinatal interventions impacting maternal sleep and maternal mental health

Author

Intervention Description

Study Design / Analytical Approach

Intervention Delivery

Intervention Facilitator

Intervention Length

Data Time Points

(PN = postnatal,

GE = gestational)

Number of Participants (Intervention vs Control)

Retention Rate

Recruitment Sites and Methods

Mental Health Measures

Sleep Measures

Results Summary

Lee et al. (2013), USA [51]

Morning bright light therapy and a 30-min discussion on principles of sleep hygiene and a sleep hygiene booklet

RCT, between group

Face-to-face individual sessions

Trained graduate research nurse

30 mins every morning for 3 weeks

• Baseline (5–10 days PN)

• Intervention end

35 enrolled 30 completed

(16 vs 14)

85%

Hospital neonatal intensive care unit

EPDS-10

SF36v2-M

GSDS-SQ

GSDS-DF

TST-NA

TST-DA

• No difference between groups for sleep quality and daytime functioning or sleep duration

• No difference between groups for depressive symptoms or mental health–related quality of life

Parry et al. (2019), USA [58]

Cross-over of one night of early-night wake therapy (EWT) and late-night wake therapy (LWT)

Single arm, pre-post

In a general clinical research centre

General clinical research centre staff

One night of either EWT or LWT separated by 1 week

• Baseline (0–34 weeks GE to 0–12 months PN)

• Intervention end

50 enrolled

26 antenatal

(17 healthy controls, 9 clinically depressed)

24 postnatal

(8 healthy controls, 16 clinically depressed)

Study Design recast

15 antenatal (EWT)

18 antenatal (LWT)

15 postnatal (EWT)

14 postnatal (LWT)

Not reported

Not reported

HAMD-21

Actigraphy

PSG

DLMO

• EWT showed greater improvement in mood in pregnant women compared to postpartum women; LWT showed greater improvement in postpartum women compared to pregnant women.

• Improved mood in pregnant women after EWT was associated with less time between melatonin onset and sleep onset. Improved mood in postpartum women after LWT was associated with increased total sleep time.

Swanson et al. (2018), USA [66]

Morning light therapy using light therapy glasses

Single arm, pre-post

Light therapy glasses, self- delivered after instruction

No personal contact

60 mins every morning for 5 weeks

• Baseline (0–6 months PN)

• Intervention end

10 enrolled

8 completed

80%

Department of Psychiatry and community advertisements

EPDS-10

SIGH-SAD

TST-D

TST-A

SE-D

SE-A

DLMO

PAD

• Improvement in depressive symptoms (EPDS and SIGH-SAD)

• Improvement in self-reported sleep efficiency

• No change in diary or actigraphy TST, actigraphic sleep efficiency, DLMO, and PAD

• Correlation between change in PAD and percent change in SIGH-SAD score (lengthening of the PAD associated with greater improvement on SIGH-SAD)

  1. DLMO Dim Light Melatonin Onset, EPDS-10 10-item Edinburgh Postnatal Depression Scale, EWT Early-Night Wake Therapy, GSDS-SQ General Sleep Disturbance Scale Sleep Quality subscale, GSDS-DF General Sleep Disturbance Scale Daytime Functioning subscale, HAMD-21 21-item Hamilton Depression Rating Scale, LWT Late-Night Wake Therapy, PAD Phase angle difference between DLMO and midpoint of sleep per wrist actigraphy, PSG Polysomnography, SF36v2-M Medical Outcomes Short Form-36, version 2, Mental subscale, SIGH-SAD Structured Interview Guide for the Hamilton Depression Rating Scale, Seasonal Affective Disorders, TST-A Total Sleep Time (actigraphy), TST-NA Total Sleep Time Nocturnal (actigraphy), TST-DA Total Sleep Time Daytime (actigraphy), TST-D Total Sleep Time (diary), SE-D Sleep Efficiency (diary), SE-A Sleep Efficiency (actigraphy)