|
Characteristics
|
TOP N (%)
|
COP N (%)
|
p-value
|
OR (95%CI)
|
|---|
|
Maternal age (mean ± SD)
|
32.8 ± 5.9
|
29.9 ± 6.1
|
< 0.001
| |
|
Maternal age (years)
| | |
< 0.001
|
2.25 (1.5–3.38)
|
|
< 35
|
153 (58)
|
149 (75.6)
| | |
|
≥35
|
111 (42.1)
|
48 (24.4)
| | |
|
Education
| | |
0.103
|
1.37 (0.94–2.01)
|
|
< Bachelor’s degree
|
94 (37)
|
87 (44.6)
| | |
|
≥ Bachelor’s degree
|
160 (63)
|
108 (55.4)
| | |
|
Gravidity
| | |
0.029
|
1.52 (1.04–2.22)
|
|
Primigravida
|
94 (35.6)
|
90 (45.7)
| | |
|
Multigravida
|
170 (64.4)
|
107 (54.3)
| | |
|
Method of conception
| | |
0.717
|
1.35 (0.27–6.74)
|
|
Natural conception
|
261 (98.9)
|
194 (98.5)
| | |
|
ART
|
3 (1.1)
|
3 (1.5)
| | |
|
Had at least one child
| | |
0.431
|
1.16 (0.8–1.68)
|
|
Yes
|
125 (47.4)
|
86 (43.7)
| | |
|
No
|
139 (52.7)
|
111 (56.4)
| | |
|
Previous history of abortion
| | |
0.314
|
1.24 (0.81–1.9)
|
|
Yes
|
74 (28)
|
47 (23.9)
| | |
|
No
|
190 (72)
|
150 (76.1)
| | |
|
Previous history of having a child with an anomaly
| | |
0.584
|
1.25 (0.56–2.81)
|
|
Yes
|
13 (4.9)
|
12 (6.1)
| | |
|
No
|
251 (95.1)
|
185 (93.9)
| | |
|
GA at diagnosis (weeks), median (IQR)
|
20 (11–23)
|
21 (12–23)
|
< 0.001
|
0.77 (0.71–0.84)
|
|
Organ system
| | |
< 0.001
|
9.37 (5.51–15.93)
|
|
Isolated
|
132 (50)
|
178 (90.4)
| | |
|
Multiple
|
132 (50)
|
19 (9.6)
| | |
|
CNS anomalies
| | |
< 0.001
|
5.69 (2.77–11.70)
|
|
Yes
|
36 (27.3)
|
11 (6.2)
| | |
|
No
|
96 (72.7)
|
167 (93.8)
| | |
|
Severity grade
| | |
< 0.001
| |
|
Lethal
|
201 (76.1)
|
36 (18.3)
| |
99.10 (34.07–288.30)
|
|
Potentially lethal
|
59 (22.4)
|
90 (45.7)
| |
11.64 (4.03–33.56)
|
|
Non-lethal
|
4 (1.5)
|
71 (36)
| | |
|
Genetic abnormalities
| | |
< 0.001
| |
|
Yes
|
121 (45.8)
|
11 (5.6)
| |
8.37 (4.18–16.77)
|
|
No
|
55 (20.8)
|
119 (60.4)
| |
0.35 (0.22–0.55)
|
|
Unknown
|
88 (33.3)
|
67 (34)
| | |
- ART assisted reproductive technology, CI confidence interval, CNS central nervous system, COP continuation of pregnancy, GA gestational age, IQR interquartile range, OD odds ratio, SD standard deviation, TOP termination of pregnancy
