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Table 3 Associations between maternal and fetal characteristics and parental decisions

From: Factors influencing parental decisions to terminate pregnancies following prenatal diagnoses of major fetal anomalies at Ramathibodi Hospital, Bangkok, Thailand

Characteristics TOP N (%) COP N (%) p-value OR (95%CI)
Maternal age (mean ± SD) 32.8 ± 5.9 29.9 ± 6.1 < 0.001  
Maternal age (years)    < 0.001 2.25 (1.5–3.38)
 < 35 153 (58) 149 (75.6)   
 ≥35 111 (42.1) 48 (24.4)   
Education    0.103 1.37 (0.94–2.01)
 < Bachelor’s degree 94 (37) 87 (44.6)   
 ≥ Bachelor’s degree 160 (63) 108 (55.4)   
Gravidity    0.029 1.52 (1.04–2.22)
 Primigravida 94 (35.6) 90 (45.7)   
 Multigravida 170 (64.4) 107 (54.3)   
Method of conception    0.717 1.35 (0.27–6.74)
 Natural conception 261 (98.9) 194 (98.5)   
 ART 3 (1.1) 3 (1.5)   
Had at least one child    0.431 1.16 (0.8–1.68)
 Yes 125 (47.4) 86 (43.7)   
 No 139 (52.7) 111 (56.4)   
Previous history of abortion    0.314 1.24 (0.81–1.9)
 Yes 74 (28) 47 (23.9)   
 No 190 (72) 150 (76.1)   
Previous history of having a child with an anomaly    0.584 1.25 (0.56–2.81)
 Yes 13 (4.9) 12 (6.1)   
 No 251 (95.1) 185 (93.9)   
GA at diagnosis (weeks), median (IQR) 20 (11–23) 21 (12–23) < 0.001 0.77 (0.71–0.84)
Organ system    < 0.001 9.37 (5.51–15.93)
 Isolated 132 (50) 178 (90.4)   
 Multiple 132 (50) 19 (9.6)   
CNS anomalies    < 0.001 5.69 (2.77–11.70)
 Yes 36 (27.3) 11 (6.2)   
 No 96 (72.7) 167 (93.8)   
Severity grade    < 0.001  
 Lethal 201 (76.1) 36 (18.3)   99.10 (34.07–288.30)
 Potentially lethal 59 (22.4) 90 (45.7)   11.64 (4.03–33.56)
 Non-lethal 4 (1.5) 71 (36)   
Genetic abnormalities    < 0.001  
 Yes 121 (45.8) 11 (5.6)   8.37 (4.18–16.77)
 No 55 (20.8) 119 (60.4)   0.35 (0.22–0.55)
 Unknown 88 (33.3) 67 (34)   
  1. ART assisted reproductive technology, CI confidence interval, CNS central nervous system, COP continuation of pregnancy, GA gestational age, IQR interquartile range, OD odds ratio, SD standard deviation, TOP termination of pregnancy