Determining antenatal medicine exposures in South African women: a comparison of three methods of ascertainment

van der Hoven, Jani; Allen, Elizabeth; Cois, Annibale; de Waal, Renee; Maartens, Gary; Myer, Landon; Malaba, Thokozile; Madlala, Hlengiwe; Nyemba, Dorothy; Phelanyane, Florence; Boulle, Andrew; Mehta, Ushma; Kalk, Emma

doi:10.1186/s12884-022-04765-1

BMC Pregnancy and Childbirth

Table 4 Inter-dataset agreement for ATC level 2 medications (Cohen’s kappa)

From: Determining antenatal medicine exposures in South African women: a comparison of three methods of ascertainment

	EDR versus Clinician Record					EDR versus Self-Report					Clinician Record versus Self-Report
	kappa	95% CI	Strength	PABAK	95% CI	kappa	95% CI	Strength	PABAK	95% CI	kappa	95% CI	Strength	PABAK	95% CI
none	0.33	0.27; 0.39	slight	0.33	0.27; 0.39	0.20	0.15; 0.24	slight	0.25	0.19; 0.31	0.09	0.04; 0.14	slight	0.10	0.04; 0.58
none + TCAM^a						0.03	-0.01; 0.08	slight	0.11	0.04; 0.17	0.06	-0.01; 0.14	slight	0.58	0.53; 0.63
A02	none PER					0.13	0.06; 0.20	slight	0.63	0.59; 0.68
A03	-0.00	0.30;-0.01	poor	0.94	0.92;0.96	-0.01	-0.02;-.00	poor	0.93	0.91;0.96	-0.00	-0.00; 0.00	poor	0.99	0.98;1.0
A06	-0.01	-0.02;-0.01	poor	0.95	0.93; 0.97	0.13	-0.05;0.30	slight	0.95	0.93;0.97	-0.01	-0.02;-0.01	poor	0.94	0.92;0.96
A07	0.16	-0.1;0.45	slight	0.98	0.97;0.99	0.37	0.11; 0.64	fair	0.97	0.96;0.99	0.15	-0.11;0.42	slight	0.98	0.96; 0.99
A10	0.26	-0.03; 0.56	fair	0.98	0.96;0.99	0.47	0.17; 0.76	moderate	0.98	0.97; 0.99	-0.00	-0.01; -0.00	poor	0.99	0.98; 1.00
A11	0.02	-0.01;0.04	slight	0.63	0.59; 0.68	0.03	-0.03;0.08	slight	0.55	0.50; 0.60	-0.00	-0.01; 0.00	poor	0.85	0.82; 0.88
A12	-0.00	-0.00;-0.00	poor	0.99	0.98; 1.0	-0.00	-0.01;-0.00	poor	0.97	0.96; 0.99	-0.00	-0.01;0.00	poor	0.98	0.96; 0.99
B01	-0.00	-0.00;-0.00	poor	1.00	0.99; 1.00	none self-report
B03	0.03	0.01; 0.05	slight	-0.40	-0.46; -0.35	0.00	-0.03; 0.03	poor	-0.36	-0.42; -0.30	0.02	-0.04; 0.08	slight	0.39	0.34; 0.45
B05	PHDC only
C01	PHDC only
C02	0.09	-0.08; 0.26	slight	0.96	0.94; 0.98	0.33	0.09; 0.57	fair	0.97	0.95; 0.98	-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00
C03	0.33	0.08; 0.57	fair	0.97	0.95; 0.98	0.16	-0.5; 0.36	slight	0.96	0.94; 0.98	0.24	-0.04; 0.53	fair	0.97	0.96; 0.99
C07	PHDC only
C08	-0.01	-0.01; -0.00	poor	0.97	0.96; 0.99	0.22	-0.14; 0.58	fair	0.99	0.97; 1.00	-0.00	-0.00; 0.00	poor	0.99	0.97; 1.00
C09	0.44	0.04; 0.85	moderate	0.99	0.98; 1.00	0.25	-0.15; 0.65	fair	0.99	0.98; 1.00	0.40	-0.15; 0.94	fair	0.99	0.99; 1.00
C10	-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00	-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00	0.33	-0.15; 0.82	fair	0.99	0.98; 1.00
D01	self-report only
D02	0.09	-0.05; 0.22	slight	0.93	0.90; 0.95	0.17	0.03; 0.30	slight	0.90	0.87; 0.92	-0.01	-0.01; 0.00	poor	0.94	0.92; 0.96
D04	-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00	-0.00	-0.00; 0.00	poor	0.98	0.97; 0.99	-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00
D06	self-report only
D07	0.20	-0.04; 0.43	slight	0.97	0.95; 0.98	0.13	-0.05; 0.31	slight	0.95	0.93; 0.97	-0.00	-0.01; 0.00	poor	0.98	0.96; 0.99
D08	-0.00	-0.00; 0.00	poor			-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00	-0.00	-0.00; 0.00	poor
G01	0.03	-0.05; 0.10	slight	0.90	0.87; 0.92	0.11	0.01; 0.21	slight	0.84	0.81; 0.87	0.06	-0.03; 0.16	slight	0.90	0.87; 0.93
G02	self-report only
G03	none PER					-0.01	-0.02; -0.01	poor	0.95	0.94; 0.97
G04	-0.01	-0.01; -0.00	poor	0.98	0.96; 0.99	0.09	-0.10; 0.27	slight	0.96	0.95; 0.98	0.09	-0.09; 0.27	slight	0.96	0.95; 0.98
H02	-0.00	-0.01; 0.00	poor	0.98	0.97; 0.99	-0.00	-0.01; 0.00	poor	0.98	0.96; 0.99	-0.00	-0.00; 0.00	poor	0.99	0.9; 1.00
H03	PHDC only
J01	0.01	-0.05; 0.06	slight	0.58	0.53; 0.63	0.24	0.16; 0.32	fair	0.64	0.59; 0.68	0.05	-0.02; 0.12	slight	0.72	0.68; 0.77
J02	PHDC only
J04	0.02	-0.01; 0.06	slight	0.65	0.60; 0.70	0.07	0.02; 0.12	slight	0.66	0.61; 0.71	-0.01	-0.01; -0.00	poor	0.97	0.96; 0.98
J07	none PHDC										0.01	-0.01; 0.03	slight	0.54	0.48; 0.59
M01	-0.00	-0.01; 0.00	poor	0.92	0.90; 0.95	0.07	-0.03; 0.16	slight	0.86	0.82; 0.89	-0.00	-0.01; 0.00	poor	0.91	0.89; 0.94
N02	0.01	-0.03; 0.05	slight	0.58	0.53; 0.64	0.07	0.02; 0.12	slight	0.04	-0.02; 0.11	0.01	-0.01; 0.03	slight	-0.03	-0.09;0.03
N03	1.00		perfect	1.00		-0.00	-0.00; 0.00	poor	1.00	0.99; 1.00	-0.00	-0.00; 0.00	poor	1.00	0.99; 1.00
N05	none PER					0.40	-0.15; 0.94	fair	0.99	0.99; 1.00
N06	-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00	-0.00	-0.01; -0.00	poor	0.99	0.98; 1.00	-0.00	-0.00; 0.00	poor	0.99	0.99; 1.00
P01	0.04	-0.04; 0.13	slight	0.86	0.82; 0.89	0.12	0.03; 0.22	slight	0.80	0.77; 0.84	0.21	0.10; 0,33	fair	0.84	0.81; 0.87
P02	PHDC only
P03	0.13	-0.10; 0.36	slight	0.97	0.96; 0.99	0.10	-0.09; .029	slight	0.96	0.95; 0.98	-0.00	-0.01; 0.00	poor	0.98	0.97; 0.99
R01	none PER					-0.01	-0.00; -0.02	poor	0.91	0.89; 0.94
R03	0.54	0.29; 0.79	moderate	0.98	0.97; 0.99	0.21	0.04; 0.40	fair	0.93	0.90; 0.95	0.10	-0.04; 0.23	slight	0.93	0.91; 0.95
R05	self-report only
R06	0.09	-0.01; 0.20	slight	0.89	0.86; 0.92	0.06	-0.02; 0.14	slight	0.76	0.71; 0.80	0.04	-0.02; 0.10	slight	0.83	0.80; 0.87
S01	-0.00	-0.00;0.00	poor	0.99	0.98; 1.00	-0.00	-0.00; 0.00	poor	0.99	0.98; 1.00	-0.00	-0.00;0.0	-0.00;0.0	1.00	0.99; 1.00
S02	PHDC only

^aExcludes TCAM and ATC medication in the self-report dataset
ACT Anatomical chemical therapeutic, PABAK Prevalence and bias-adjusted kappa, EDR Electronic dispensing record, TCAM Traditional, complementary, alternative medicines

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ISSN: 1471-2393

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