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Table 2 Documented clinical and non-clinical modifiable factors identified in 12 maternal deaths and 19 near-miss cases

From: International virtual confidential reviews of infection-related maternal deaths and near-miss in 11 low- and middle-income countries – case report series and suggested actions

Modifiable factors

 
 

Maternal deaths (N = 85)

Near-miss

(N = 66)

n (%)

n (%)

Delay in decision to seek care

2 (2.4)

3 (4.5)

 Late antenatal care

0

2

 Delay in deciding to seek appropriate medical help

2

1

Delay in reaching the GLOSS facilitya

5 (5.9)

1 (1.5)

 Delay in referral to a higher-level facility

5

1

Delay in receiving care

71 (83.4)

55 (83.3)

Prior to arrival to the level 3 facility

6 (7.0)

8 (12.1)

  Delivered by a traditional birth attendant

1

3

  Inadequate management of preexisting conditions

2

3

  Missing referral information

3

2

Clinical and laboratory examinations

20 (23.5)

17 (25.8)

  Inadequate clinical examination at admission

3

2

  Inadequate monitoring after admission

5

2

  Missing or delayed microbiological cultureb

7

7

  Missing or delayed other laboratory & diagnostics

5

6

Diagnosis

13 (15.3)

12 (18.2)

  Incorrect working diagnosis during case management

6

2

  Incomplete main diagnosis

3

0

  Delayed diagnosis

0

1

  Criteria for diagnosis not met

4

4

  Source of infection not identified

0

2

  Near-miss criteria (based on WHO definition) not metc

0

3

  Missing diagnosis

0

0

Management

32 (37.6)

18 (27.3)

  Incomplete clinical management of infectiond

2

1

  Suboptimal use of antibioticse

9

6

  Delay or overuse of other medicationsf

5

6

  Insufficient intravenous fluid

2

0

  Insufficient blood transfusion

2

0

  Delayed ICU/HDU admissiong

6

3

  Delayed control of the source of infection

3

1

  Missing or delayed interventionsh

3

1

Other clinical factors

1 (1.2)

4 (6.1)

 Antimicrobial resistance

1

1

 Unexplained prolonged hospitalizationi

0

3

Non-clinical factors

6 (7.1)

3 (4.5)

 Incomplete multidisciplinary teamj

3

2

 Delayed mobilization of the managing team

1

0

 Restrictive abortion policies and legislation

1

0

 Stigma of preexisting condition as a potential care barrier

0

1

 Discharge against medical advice

1

 
  1. aAll GLOSS facilities in this study are level 3 health facilities
  2. bBacterial culture from blood, urine, respiratory tract
  3. cNear-miss were identified by countries according to the GLOSS protocol criteria. However, cross-check by the review team revealed 3 cases that did not meet the criteria
  4. dManagement focused on other conditions and not the infection
  5. eIncludes delayed, wrong and overuse of antibiotics
  6. fAntivirals, antifungal, steroids, antimalaria, diuretic and inotropic agents
  7. gICU=Intensive Care Unit; HDU = High Dependency Unit
  8. hInterventions include induction/birth, manual removal of placenta, dilation and curettage, emergency laparotomy, hysterectomy
  9. iProlonged hospitalization was assessed based on the reported improvement in the clinical status of the woman
  10. jMultidisciplinary team characterized by a minimum of an obstetrician-gynecologist and anesthesiologist plus any additional specialist needed depending on the case
  11. Key: GLOSS-Global Sepsis Study