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Table 4 Multivariable analysis of perinatal risk factors for infant mortality at different periods by Cox regression model

From: Perinatal Risks of Neonatal and Infant Mortalities in a Sub-provincial Region of China: A Livebirth Population-based Cohort Study

 

Adjusteda HR (95% CI)

 

Early neonatal death

Late neonatal death

Postneonatal death

GA 25-27 (week)

2.99 (1.10, 8.16)*

0.59 (0.09, 3.81)

33.31 (12.23, 90.72)***

28-31

3.62 (1.53, 8.58)**

1.02 (0.29, 3.66)

2.31 (0.72, 7.41)

32-36

2.15 (1.08, 4.27)*

0.34 (0.12, 1.02)

0.39 (0.13, 1.19)

37-38

1.62 (1.00, 2.65)

1.34 (0.64, 2.81)

0.72 (0.39, 1.32)

39-41

1.00 (Reference)

1.00 (Reference)

1.00 (Reference)

>  42

–

9.77 (2.24, 42.69)**

1.52 (0.21, 11.10)

BW < 1000 (g)

27.15 (10.36, 71.16)***

86.88 (12.37, 610.07)***

NI

1000-1499

4.26 (1.85, 9.79)**

9.08 (2.48, 33.24)**

NI

1500-2499

2.02 (1.08, 3.78)*

4.76 (2.02, 11.24)***

NI

2500-3999

1.00 (Reference)

1.00 (Reference)

NI

>  4000

0.19 (0.05, 0.79)*

1.17 (0.40, 3.41)

NI

Maternal age < 20 (y)

NI

2.54 (0.90, 7.21)

NI

20-34

NI

1.00 (Reference)

NI

>  35

NI

2.32 (1.18, 4.58)*

NI

Rural residency

1.41 (0.96, 2.09)

NI

NI

Education > 9 y

0.66 (0.45, 0.96)*

NI

0.59 (0.36, 0.97)*

PROM

NI

1.89 (1.02, 3.51)*

NI

Umbilical cord

1.82 (1.07, 3.08)*

NI

NI

Antenatal steroids

0.42 (0.26, 0.68)***

NI

NI

AF contamination

2.03 (1.36, 3.01)***

2.00 (1.07, 3.73)*

NI

Multiple births

NI

NI

4.31 (2.02, 9.23)***

Apgar 5-min < 7

17.89 (11.40, 28.07)***

1.90 (0.92, 3.92)

NI

Congenital anomalies

3.18 (2.13, 4.75)***

12.07 (6.85, 21.27)***

6.90 (3.61, 13.19)***

Hospitalization

3.03 (1.92, 4.80)***

31.41 (10.64, 92.67)***

3.30 (1.91, 5.71)***

  1. Abbreviations: HR Hazard ratio, in comparison with the subgroups in reference, CI Confidence interval, GA Gestational age, BW Birthweight, PROM Prelabor rupture of membrane, AF Amniotic fluid, NI Not included. * P < 0.05, ** P < 0.01, and *** P < 0.001 for comparisons with the reference group
  2. a. Adjusted by all evaluated perinatal factors listed in the table but not those variables presenting as NI, i.e. not included in the final step of multivariable Cox regression model with backward stepwise selection