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Table 5 Maternal diseases associated with neonatal jaundice identified from the matched samples in studies A and B

From: Maternal disease factors associated with neonatal jaundice: a case–control study

 

Univariable

Multivariable

Disease (diagnosis code)

Jaundice group

Control group

Unadjusted odds ratio (95% CI)

p-value*

Jaundice group

Control group

Adjusted odds ratio (95% CI) [p-value*]

Disease

Preterm

C-section

Multiple gestation

ANC duration

Study A

366 cases

3,660 cases

  

366 cases

3,660 cases

     

Other diseases of digestive system (K92)

4 (1.1)

3.80 (0.1)

13.97 (2.21–238.30)

0.004

4 (1.1)

3.89 (0.1)

14.12 (2.70–82.26)

[0.003*]

0.54 (0.21–1.38)

[0.208]

1.55 (1.24–1.93)

[< 0.001*]

1.60 (0.79–3.21)

[0.234]

0.99 (0.99–1.00)

[< 0.001*]

Other surgical follow-up care (Z48)

6 (1.6)

9.82 (0.3)

6.96 (1.97–24.24)

0.003

6 (1.6)

9.82 (0.3)

6.18 (2.09–18.53)

[0.003*]

0.53 (0.21–1.37)

[0.200]

1.51 (1.21–1.89)

[< 0.001*]

1.71 (0.86–3.40)

[0.166]

0.99 (0.99–1.00)

[< 0.001*]

Other and unspecified syphilis (A53)

8 (2.2)

17.52 (0.5)

4.94 (1.81–12.47)

0.002

8 (2.2)

17.52 (0.5)

5.24 (2.18–12.61)

[< 0.001*]

0.53 (0.21–1.37)

[0.201]

1.56 (1.25–1.95)

[< 0.001*]

1.69 (0.85–3.36)

[0.177]

0.99 (0.99–1.00)

[< 0.001*]

Leiomyoma of uterus (D25)

11 (3.0)

34.75 (0.9)

3.32 (1.50–6.80)

0.003

11 (3.0)

34.77 (1.0)

3.22 (1.59–6.52)

[0.003*]

0.53 (0.21–1.36)

[0.198]

1.54 (1.23–1.92)

[< 0.001*]

1.66 (0.83–3.30)

[0.194]

0.99 (0.99–1.00)

[< 0.001*]

Vasomotor and allergic rhinitis (J30)

21 (5.7)

357.13 (9.8)

0.56 (0.34–0.89)

0.014

21 (5.7)

359.79 (9.8)

0.58 (0.37–0.92)

[0.024*]

0.54 (0.21–1.38)

[0.207]

1.55 (1.24–1.94)

[< 0.001*]

1.67 (0.84–3.32)

[0.187]

0.99 (0.99–1.00)

[< 0.001*]

Acute tonsillitis (J03)

11 (3.0)

224.56 (6.1)

0.48 (0.23–0.88)

0.016

11 (3.0)

226.83 (6.2)

0.49 (0.26–0.91)

[0.025*]

0.53 (0.21–1.36)

[0.197]

1.55 (1.24–1.94)

[< 0.001*]

1.67 (0.84–3.32)

[0.186]

0.99 (0.99–1.00)

[< 0.001*]

Acute bronchitis (J20)

12 (3.3)

258.30 (7.1)

0.45 (0.23–0.81)

0.006

12 (3.3)

258.49 (7.1)

0.47 (0.26–0.84)

[0.013*]

0.53 (0.21–1.36)

[0.198]

1.55 (1.24–1.94)

[< 0.001*]

1.67 (0.84–3.31)

[0.187]

0.99 (0.99–1.00)

[< 0.001*]

Gastritis and duodenitis (K29)

13 (3.6)

326.31 (8.9)

0.38 (0.20–0.66)

 < 0.001

13 (3.6)

326.31 (8.9)

0.39 (0.22–0.69)

[0.001*]

0.53 (0.21–1.36)

[0.199]

1.55 (1.24–1.94)

[< 0.001*]

1.76 (0.88–3.50)

[0.149]

0.99 (0.99–1.00)

[< 0.001*]

Study B

298 cases

2,980 cases

  

298 cases

2,980 cases

     

Salpingitis and oophoritis (N70)

10 (3.4)

31.30 (1.1)

3.37 (1.45–7.20)

0.005

10 (3.4)

31.36 (1.1)

3.33 (1.59–6.94)

[0.003*]

0.30 (0.07–1.27)

[0.106]

1.42 (1.11–1.82)

[0.007*]

1.47 (0.63–3.44)

[0.421]

1.00 (0.99–1.00)

[0.051]

Gastritis and duodenitis (K29)

111 (37.2)

1,332.70 (44.7)

0.73 (0.57–0.94)

0.017

111 (37.2)

1,336.31 (44.8)

0.75 (0.58–0.95)

[0.023*]

0.30 (0.07–1.28)

[0.108]

1.43 (1.12–1.83)

[0.006*]

1.53 (0.66–3.55)

[0.372]

1.00 (0.99–1.00)

[0.092]

Vasomotor and allergic rhinitis (J30)

92 (30.9)

1,210.73 (40.6)

0.65 (0.50–0.85)

0.002

92 (30.9)

1,210.73 (40.6)

0.66 (0.51–0.86)

[0.003*]

0.30 (0.07–1.27)

[0.107]

1.43 (1.12–1.83)

[0.006*]

1.53 (0.66–3.54)

[0.376]

1.00 (0.99–1.00)

[0.102]

Dyspepsia (K30)

35 (11.7)

576.78 (19.4)

0.56 (0.37–0.80)

0.001

35 (11.7)

576.78 (19.4)

0.56 (0.39–0.81)

[0.003*]

0.30 (0.07–1.28)

[0.109]

1.43 (1.12–1.83)

[0.006*]

1.57 (0.68–3.64)

[0.347]

1.00 (0.99–1.00)

[0.093]

Other disorders of nose and nasal sinuses (J34)

7 (2.3)

171.37 (5.8)

0.40 (0.16–0.85)

0.014

7 (2.3)

172.14 (5.8)

0.40 (0.19–0.87)

[0.022*]

0.30 (0.07–1.26)

[0.104]

1.42 (1.11–1.81)

[0.007*]

1.55 (0.67–3.59)

[0.358]

1.00 (0.99–1.00)

[0.064]

Heartburn (R12)

5 (1.7)

168.43 (5.7)

0.29 (0.09–0.69)

0.002

5 (1.7)

168.43 (5.7)

0.29 (0.12–0.71)

[0.008*]

0.30 (0.07–1.28)

[0.108]

1.43 (1.12–1.83)

[0.006*]

1.54 (0.67–3.57)

[0.365]

1.00 (0.99–1.00)

[0.066]

  1. The number and ratio of cases in each group were presented as N (%). The average number of cases, average odds ratio, and mean p-values for significant results from 1,000 matched samples were calculated. Conditional logistic regression analyses, adjusted for preterm delivery, delivery mode, multiple gestation and ANC duration, were performed for the diseases showing more than 900 significant results in the univariable analyses
  2. *Significance at p-value < 0.05
  3. CI Confidence interval