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Table 2 Laboratory outcomes stratified by MTHFR C677T genotype

From: MTHFR 677TT is associated with decreased number of embryos and cumulative live birth rate in patients undergoing GnRHa short protocol: a retrospective study

 

Total N=1173

Long protocol N=730

Short protocol N=443

 

CC N=500

CT N=546

TT N=127

P-value

CC N=297

CT N=348

TT N=85

P-value

CC N=203

CT N=198

TT N=42

P-value

Oocytes

10.33 (4.41)

10.14 (4.24)

9.83 (4.00)

0.463

10.64 (4.39)

10.53 (4.22)

10.33 (4.08)

0.838

9.89 (4.41)

9.44 (4.20)

8.81 (3.65)

0.269

Transferable embryos

4.28 (2.57)

4.17 (2.41)

3.88 (2.21)

0.254

4.23 (2.54)

4.09 (2.31)

4.20 (2.38)

0.763

4.36 (2.62) aNS

4.31 (2.58) b**

3.24 (1.66) c**

0.028

Good-quality embryos

3.88 (2.35)

3.80 (2.23)

3.40 (1.92)

0.102

3.85 (2.30)

3.74 (2.14)

3.76 (2.06)

0.796

3.92 (2.42) aNS

3.90 (2.40) b***

2.67 (1.34) c***

0.005

  1. Note: The continuous variables were presented as mean (SD) and analyzed by ANOVA analysis. P < 0.05 was considered as statistically significant. MTHFR 5,10-Methylenetetrahydrofolate reductase. a: CC versus CT. b: CT versus TT. c: TT versus CC. * P < 0.05, ** P < 0.01, *** P < 0.001, NS: not significant. P-values of post-hoc multivariate comparisons under GnRHa short protocol: For the number of transferable embryos: CC versus CT (p-value=0.858), CT versus TT (p-value=0.001); TT versus CC (p-value=0.001). For the number of good-quality embryos: CC versus CT (p-value=0.943), CT versus TT (p-value<0.001), TT versus CC (p-value<0.001)
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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