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Table 4 Adjusted Odds Ratios and 95% Confidence Intervals by Vaccination Trimester

From: Safety of SARS-CoV-2 vaccination during pregnancy- obstetric outcomes from a large cohort study

Outcome

Second Trimester

Third Trimester

Unvaccinated

Primary Outcomes

Preterm birth

1.49 (1.11, 2.01)

0.49 (0.34, 0.71)

referent

Small for gestational age

0.73 (0.52, 1.03)

0.85 (0.64, 1.13)

referent

Secondary Outcomes

Cesarean delivery

1.05 (0.85, 1.30)

0.88 (0.72, 1.07)

referent

Postpartum hemorrhage (> 500 mL)

1.11 (0.71, 1.74)

1.22 (0.83, 1.78)

referent

Intrauterine fetal demise

1.12 (0.52, 2.38)

0.25 (0.08, 0.82)

referent

5 min Apgar < 7

  

referent

Umbilical pH < 7.1

1.46 (0.99, 2.14)

0.88 (0.60, 1.30)

referent

Hypertensive disorder of pregnancy

0.71 (0.33, 1.54)

0.83 (0.45, 1.55)

referent

Gestational diabetes

1.21 (0.93, 1.58)

0.99 (0.77, 1.27)

referent

  1. Odds ratios adjusted for nulliparity, maternal age, body mass index, and maternal smoking