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Table 6 Multivariable logistic regression analysis on risk factors for pregnancy outcomes in long-acting GnRH-a long protocol

From: Effects of immediate versus delayed frozen embryo transfer in high responder patients undergoing freeze-all cycles

Potential risk factor variables

Adjusted OR* (95% CI)

P-value

Clinical pregnancy

 FET timing (Immediate FETa versus delayed FETb)

0.607 (0.322–1.147)

NS

 Age (35–37 versus ≤34)

1.218 (0.471–3.150)

NS

 Age (≥38 versus ≤34)

0.810 (0.1052–6.257)

NS

 BMI (< 18.5 versus 18.5–24.9)

0.980 (0.293–3.277)

NS

 BMI (≥25 versus 18.5–24.9)

1.525 (0.715–3.256)

NS

 Insemination method (ICSI versus IVF)

1.151 (0.463–2.862)

NS

 Top or good quality embryo transfer (yes versus no)

8.805 (2.515–30.827)

P < 0.01

 Embryo stage (blastocyst versus cleavage)

1.425 (1.163–5.056)

P < 0.05

 Tubal factor (yes versus no)

2.454 (0.924–6.518)

NS

 Ovulatory disorder (yes versus no)

0.840 (0.229–3.085)

NS

 Male factor (yes versus no)

2.844 (1.147–7.051)

P < 0.05

 Unexplained factor (yes versus no)

1.335 (0.204–8.721)

NS

Spontaneous abortion

Adjusted OR# (95% CI)

 

 FET timing (Immediate FETa versus delayed FETb)

0.380 (0.143–1.010)

NS

 Age (35–37 versus ≤34)

0.409 (0.088–1.878)

NS

 Age (≥38 versus ≤34)

–

NS

 BMI (< 18.5 versus 18.5–24.9)

0.544 (0.066–4.491)

NS

 BMI (≥25 versus 18.5–24.9)

1.914 (0.759–4.827)

NS

 Top or good quality embryo transfer (yes versus no)

0.836 (0.207–3.375)

NS

Live birth

Adjusted OR* (95% CI)

P-value

 FET timing (Immediate FETa versus delayed FETb)

0.995 (0.543–1.823)

NS

 Age (35–37 versus ≤34)

2.034 (0.800–5.168)

NS

 Age (≥38 versus ≤34)

1.991 (0.248–15.991)

NS

 BMI (< 18.5 versus 18.5–24.9)

1.290 (0.396–4.195)

NS

 BMI (≥25 versus 18.5–24.9)

1.034(0.507–2.111)

NS

 Insemination method (ICSI versus IVF)

1.422 (0.607–3.334)

NS

 Top or good quality embryo transfer (yes versus no)

13.211 (2.621–66.596)

P < 0.01

 Embryo stage (blastocyst versus cleavage)

2.339 (1.186–4.614)

P < 0.05

 Tubal factor (yes versus no)

2.025 (0.842–4.868)

NS

 Ovulatory disorder (yes versus no)

0.552 (0.148–2.057)

NS

 Male factor (yes versus no)

1.470 (0.658–3.286)

NS

 Unexplained factor (yes versus no)

0.397 (0.054–2.935)

NS

  1. Abbreviations: BMI, body mass index; FET, frozen embryo transfer; GnRH-a, gonadotrophin-releasing hormone agonist; IVF, in vitro fertilization; ICSI, intracytoplasmic sperm injection; OR, odds ratio; CI, confidence interval; NS, not significant
  2. aImmediate FET and bdelayed FET means FET took place either within the first menstrual cycle following oocyte retrieval or afterwards
  3. *Using the multivariable logistic regression and adjusting for maternal age, BMI, insemination method, trigger type, embryo stage, top or good quality embryo transfer, and cause of infertility
  4. # Using the multivariable logistic regression and adjusting for maternal age, BMI, top or good quality embryo transfer
  5. “-” means that the number of miscarriages in the group over 38 years old is 0.
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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