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Table 1 Literature search and study characteristic

From: Are prenatal anxiety or depression symptoms associated with asthma or atopic diseases throughout the offspring’s childhood? An updated systematic review and meta-analysis

Author, Year

Country

Study Design

N

Exposure (age measured)

Diagnosis of exposure

Outcome and age measured of the outcome

Effect measure

Covariates

Cookson, 2009 [10]

UK, Europe

Prospective cohort study

5810

Anxiety symptom (32 weeks of gestation)

Crown-Crisp index

Asthma (7.5-y)

aOR = 1.03 (0.86,1.23)

Partner's self-reported anxiety symptom scores during pregnancy

Magnus, 2017 [21]

Norway, Europe

Prospective cohort study

63,626

Major depression (30 weeks pregnancy)

SCL-5

Asthma (7-y)

aOR = 1.17 (1.06,1.29)

Maternal age, parity, education, pregnancy body mass index, smoking during pregnancy, and history of asthma

Letourneau, 2017 [22]

Canada, North America

Prospective cohort study

242

Anxiety (32–40 weeks of gestation)

EDS, SCL-90-R

AD (18-month)

aOR = 2.78 (1.04,7.39)

Maternal unresponsiveness and controlling, postnatal depression, social support and anxiety, pregnancy specific anxiety, maternal asthma

Elbert, 2017 [23]

Netherlands, Europe

Prospective cohort study

5205

Depression (2nd trimester of pregnancy)

Brief Symptom Inventory

AD (9-10y)

1. inhalant aOR = 2.07 (1.43,2.97)

2. food aOR = 0.75 (0.29,0.97)

Maternal age at enrollment, education,

ethnic origin, parity, pet keeping, BMI at enrollment, smoking and history of allergy, eczema or asthma, and child's sex, gestational age, birth weight, child's ever breastfeeding and day care attendance

Brew, 2018 [12]

Sweden, Europe

Retrospective cohort study

360,526

Depression or anxiety (continuously through preconception, pregnancy)

SCARED, SMFQ

Asthma (5-y)

aOR = 1.44 (1.34,1.56)

Sex, gestational age, birthweight, maternal age, parental country of birth, atopic status of twin 2

Liu, 2019 [16]

Denmar, Europe

Retrospective cohort study

547,533

Negative life events (1 year before conception until delivery)

ICD (10th revision)

Asthma (0 to 6-year)

1. Early-onset transient asthma aPR = 1.02 (0.99,1.06) 2. Early-onset persistent asthma aPR = 1.04 (0.99,1.08) 3. Late-onset asthma aPR = 0.99 (0.93–1.05)

Maternal age at delivery, education at conception, smoking during pregnancy, parity, comorbidity before delivery, parental atopic status, calendar year of birth, negative life events, job demands, and job control

Radhakrishnan, 2018 [24]

Canada, North America

Retrospective cohort study

122,333

Mental health service use (during pregnancy)

NA

Asthma (12-y)

aOR = 1.16 (1.12,1.20)

Maternal history of asthma, the child’s socioeconomic status using neighborhood income quintile as a proxy, urban versus rural residence at birth, sex, low birthweight, and the presence of childhood comorbid illnesses

van der leek, 2020 [25]

Canada, North America

Retrospective cohort study

9995

Maternal distress (both pre and postnatal)

ICD (9th revision)

AD, Asthma (5-, 7-year)

1. AD: aOR = 1.27 (1.11, 1.46)

2.Asthma: aOR = 1.57 (1.29,1.91)

Preterm birth, maternal age, atopy status, urban residence, infant sex and antibiotic treatment

Hamann, 2018 [26]

Denmark, Europe

Case–control

94,622

Depression (during pregnancy)

HAMD

AD (before 5-y)

1. Compared to general population: aOR = 1.12 (0.97, 1.29)

2. Compared to pediatric hospital/clinic population: aOR = 0.91 (0.79, 1.05)

Age, sex, parental AD, and socioeconomic position

  1. ICD International Classification of Disease, SCL-5 5-item symptom checklist, SCARED Screen for Child Anxiety Related Emotional Disorders, SMFQ Shortened Mood and Feelings, EDS Edinburgh depression scale, aOR adjusted odds ratio, AD Atopic dermatitis