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Table 3 Analysis of association between SGA twin newborns and neonatal outcomes based on twin birthweight reference

From: Should singleton birth weight standards be applied to identify small-for-gestational age twins?: analysis of a retrospective cohort study

Outcomes Non-SGA
(n = 5,611)
SGA
(n = 443)
Unadjusted OR (95 % CI) P-value Adjusted OR (95 % CI)* P-value
Neonatal unit admission 2153 (38.4) 354 (79.9) 3.68 (3.13–4.34) < 0.001 7.72 (6.01–9.91) < 0.001
Neonatal jaundice 1554 (27.7) 264 (59.6) 2.58 (2.20–3.03) < 0.001 4.09 (3.30–5.09) < 0.001
NRDS 475 (8.5) 58 (13.1) 1.05 (0.85–1.30) 0.674 1.25 (0.90–1.75) 0.187
Neonatal asphyxia 128 (2.3) 14 (3.2) 1.24 (0.75–2.07) 0.397 1.22 (0.69–2.13) 0.498
Ventilator support 410 (7.3) 51 (11.5) 1.35 (1.05–1.75) 0.021 1.94 (1.32–2.85) 0.001
HIE 15 (0.3) 3 (0.7) 2.54 (0.73–8.82) 0.141 2.06 (0.57–7.36) 0.268
ICH 21 (0.4) 4 (0.9) 2.50 (0.86–7.22) 0.091 2.05 (0.68–6.13) 0.201
Sepsis 60 (1.1) 8 (1.8) 1.60 (0.75–3.41) 0.219 1.54 (0.71–3.31) 0.273
BPD 54 (1.0) 10 (2.3) 2.33 (1.20–4.52) 0.013 2.61 (1.18–5.78) 0.018
Neonatal death 19 (0.3) 5 (1.1) 3.00 (1.08–8.28) 0.034 2.34 (0.82–6.71) 0.113
Severe composite outcome 113 (2.0) 16 (3.6) 1.74 (1.04–2.91) 0.035 1.93 (1.07–3.47) 0.028
  1. aAdjusted for gestational age at delivery, nulliparity, maternal age, chorionicity, use of ART, PE and GDM. NRDS neonatal respiratory distress syndrome, HIE, hypoxic ischemic encephalopathy, ICH intracranial hemorrhage, BPD bronchopulmonary dysplasia, OR odds ratio; ART assisted reproductive technology, PE pre-eclampsia, GDM gestational diabetes mellitus