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Table 3 Analysis of association between SGA twin newborns and neonatal outcomes based on twin birthweight reference

From: Should singleton birth weight standards be applied to identify small-for-gestational age twins?: analysis of a retrospective cohort study

Outcomes

Non-SGA

(n = 5,611)

SGA

(n = 443)

Unadjusted OR (95 % CI)

P-value

Adjusted OR (95 % CI)*

P-value

Neonatal unit admission

2153 (38.4)

354 (79.9)

3.68 (3.13–4.34)

< 0.001

7.72 (6.01–9.91)

< 0.001

Neonatal jaundice

1554 (27.7)

264 (59.6)

2.58 (2.20–3.03)

< 0.001

4.09 (3.30–5.09)

< 0.001

NRDS

475 (8.5)

58 (13.1)

1.05 (0.85–1.30)

0.674

1.25 (0.90–1.75)

0.187

Neonatal asphyxia

128 (2.3)

14 (3.2)

1.24 (0.75–2.07)

0.397

1.22 (0.69–2.13)

0.498

Ventilator support

410 (7.3)

51 (11.5)

1.35 (1.05–1.75)

0.021

1.94 (1.32–2.85)

0.001

HIE

15 (0.3)

3 (0.7)

2.54 (0.73–8.82)

0.141

2.06 (0.57–7.36)

0.268

ICH

21 (0.4)

4 (0.9)

2.50 (0.86–7.22)

0.091

2.05 (0.68–6.13)

0.201

Sepsis

60 (1.1)

8 (1.8)

1.60 (0.75–3.41)

0.219

1.54 (0.71–3.31)

0.273

BPD

54 (1.0)

10 (2.3)

2.33 (1.20–4.52)

0.013

2.61 (1.18–5.78)

0.018

Neonatal death

19 (0.3)

5 (1.1)

3.00 (1.08–8.28)

0.034

2.34 (0.82–6.71)

0.113

Severe composite outcome

113 (2.0)

16 (3.6)

1.74 (1.04–2.91)

0.035

1.93 (1.07–3.47)

0.028

  1. aAdjusted for gestational age at delivery, nulliparity, maternal age, chorionicity, use of ART, PE and GDM. NRDS neonatal respiratory distress syndrome, HIE, hypoxic ischemic encephalopathy, ICH intracranial hemorrhage, BPD bronchopulmonary dysplasia, OR odds ratio; ART assisted reproductive technology, PE pre-eclampsia, GDM gestational diabetes mellitus