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Table 2 Demographic, clinical and laboratory data for the “top cycle” selected population after blastocyst transfers or cleaved embryo transfer. Analysis between pregnant and not pregnant women

From: Progesterone levels on the human chorionic gonadotropin trigger day affect the pregnancy rates for embryos transferred at different stages of development in both general and selected IVF/ICSI populations

Variables Blastocyst Blastocyst p Cleaved embryo Cleaved embryo p
  Pregnancy No pregnancy   Pregnancy No pregnancy  
Female age (y.o) 30.7 ± 2.4 31.0 ± 2.8 NS 30.4 ± 2.5 30.3 ± 2.3 NS
Female BMI (kg/m2) 25.2 ± 4.5 24.7 ± 2.1 NS 25.7 ± 4.9 24.8 ± 4.1 NS
Female smoking, % 26.7 19.5 e NS 31.2 29.9 f NS
Male BMI (kg/m2) 25.1 ± 3.3 25.3 ± 4.3 NS 25.3 ± 4.0 25.2 ± 4.2 NS
Male smoking, % 34.2 28.3 g NS 38.7 38.0 h NS
Primary infertility, % 40.0 c 43.8 a NS 61.0 d 66.8 b NS
Indications %       
Tubal disorder 16.1 15.0 NS 15.2 13.7 NS
Endometriosis 6.6 8.2 NS 7.6 6.8 NS
Ovulatory dysfunction 8.5 11.8 NS 3.8 4.8 NS
Low ovarian reserve 6.6 5.1 NS 9.1 8.5 NS
Unexplained 11.4 10.8 NS 10.6 9.7 NS
Male factor 30.4 30.4 NS 37.4 38.4 NS
Mixed 20.4 18.8 NS 16.0 17.8 NS
AMH ng/ml 3.70 ± 2.19 4.10 ± 3.60 NS 3.41 ± 1.99 3.70 ± 3.39 NS
Retrieval rank (m ± SD) 0.53 ± 0.50 g 0.65 ± 0.47 e <  0.05 0.67 ± 0.46 h 0.54 ± 0.50 f <  0.02
Number of cycles 105 194   131 247  
Total dose Gnt (IU) 2125 ± 721 1913 ± 670 <  0.02 2203 ± 853 1965 ± 813 <  0.01
FSH use, % 34.2 a 39.1 a NS 64.8 b 61.9 b NS
Stimulation duration (d) 10.0 ± 1.58 10.22 ± 2.96 NS 10.1 ± 1.5 10.1 ± 2.7 NS 
Mature follicle hCG day 2.52 ± 2.25 3.11 ± 2.98 c NS 2.82 ± 2.72 2.22 ± 2.00 d <  0.05
Estradiol hCG day-2 1155 ± 586 1264 ± 513 NS 1142 ± 584 1235 ± 513 NS
Estradiol hCG day-1 1624 ± 630 1706 ± 593 NS 1601 ± 584 1608 ± 681 NS
Estradiol hCG day 1899 ± 573 2039 ± 628 NS 1832 ± 583 2012 ± 665 <  0.01
Progesterone hCG day-2 0.75 ± 0.21 0.76 ± 0.29 NS 0.76 ± 0.23 0.75 ± 0.28 NS
Progesterone hCG day-1 0.78 ± 0.26 0.89 ± 0.27 <  0.001 0.78 ± 0.28 0.87 ± 0.28 <  0.01
Progesterone hCG day 0.86 ± 0.21 0.99 ± 0.39 <  0.001 0.86 ± 0.21 1.00 ± 0.39 <  0.001
LH hCG day-2 2.73 ± 1.86 1.61 ± 1.39 <  0.001 2.66 ± 1.72 1.55 ± 1.31 <  0.001
LH hCG day-1 1.42 ± 0.81 1.34 ± 1.16 NS 1.51 ± 0.83 1.41 ± 1.27 NS
LH hCG day 2.15 ± 1.30 1.58 ± 1.47 <  0.001 2.25 ± 1.31 1.68 ± 1.43 <  0.001
Endometrium (mm) 9.63 ± 1.47 9.54 ± 1.78 NS 9.66 ± 1.51 9.53 ± 1.75 NS
Stimulation cancelled 5 (4.7%) 11 (5.6%) NS 6 (4.5%) 13 (5.2%) NS
Number oocyte retrievals 100 183   125 234  
Retrieved oocytes (m ± SD) 8.73 ± 3.25 9.89 ± 3.74 <  0.01 8.16 ± 3.24 9.26 ± 3.81 <  0.01
Mature oocytes (m ± SD) 7.38 ± 2.64 7.96 ± 3.06 NS 6.85 ± 2.71 7.35 ± 3.19 NS
ICSI, % 34.6 a 32.9 a NS 57.3 b 53.7 b NS
2 PN (m ± SD) 5.40 ± 2.40 6.06 ± 2.68 c < 0.05 4.90 ± 2.44 5.36 ± 2.87 d NS
Fertilization rate, % 74.3 76.1 NS 72.5 72.9 NS
Total embryos (m ± SD) 5.18 ± 2.35 6.15 ± 2.55 c < 0.01 4.94 ± 2.45 5.48 ± 2.71 d NS
Cleavage rate, % 75.4 77.3 NS 73.1 74.5 NS
Blastocyst (m ± SD) 2.93 ± 1.77 3.25 ± 1.91 NS  
% Blastocyst/embryo 53.5 52.7 NS  
Culture failure 40 (40.0%) 75 (40.9%) NS 50 (40.0%) 100 (42.7%) NS
Number of transfers 60 108   75 134  
Embryo transferred (m ± SD) 1.15 ± 0.34 1.13 ± 0.33 NS 1.17 ± 0.37 1.14 ± 0.35 NS
  1. Legends: IU: international unit; Gnt: gonadotropin; endometrium: endometrial thickness
  2. Statistical analysis: The “p” column indicates the difference between pregnant and not pregnant women in cases of blastocyst or cleaved embryo transfer
  3. Difference between blastocyst and cleaved embryo transfers: a-b: p < 0.001, c-d: p < 0.01, e-f: p < 0.02, g-h: p < 0.05