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Table 1 Demographic, clinical and laboratory data for the general population after blastocyst or cleaved embryo transfer. Analysis between pregnant and not pregnant women

From: Progesterone levels on the human chorionic gonadotropin trigger day affect the pregnancy rates for embryos transferred at different stages of development in both general and selected IVF/ICSI populations

Variables Blastocyst Blastocyst p Cleaved embryo Cleaved embryo p
  Pregnancy No pregnancy   Pregnancy No pregnancy  
Female age (y.o) 33.8 ± 6.8 33.4 ± 7.8 NS 33.1 ± 7.4 33.7 ± 9.2 NS
Female BMI (kg/m2) 24.8 ± 4.5 25.0 ± 5.0 NS 25.2 ± 4.7 24.9 ± 4.2 NS
Female tobacco % 50.0 c 32.0 g <  0.001 35.0 d 24.6 h <  0.05
Male BMI (kg/m2) 25.1 ± 3.3 25.2 ± 3.8 NS 25.4 ± 7.3 24.8 ± 8.7 NS
Male tobacco % 51.8 33.0 c <  0.001 43.8 44.0 d NS
Primary infertility % 65.0 60.8 NS 59.6 62.5 NS
Indications %       
Tubal disorder 16.2 17.9 NS 15.7 13.9 NS
Endometriosis 6.3 7.7 NS 7.1 6.0 NS
Ovulatory dysfunction 6.8 7.0 NS 3.5 4.6 NS
Low ovarian reserve 5.6 6.0 NS 10.7 10.7 NS
Unexplained 14.5 9.9 NS 11.4 8.9 NS
Male factor 28.7 33.6 NS 35.7 35.0 NS
Mixed 21.8 17.9 NS 15.7 21.0 NS
AMH, ng/ml 3.46 ± 2.41 a 3.05 ± 2.70 a NS 1.95 ± 0.66 b 2.07 ± 1.10 b NS
Retrieval rank (m ± SD) 1.05 ± 0.9 1.14 ± 0.9 e NS 1.17 ± 1.0 1.34 ± 1.3 f NS
Number of cycles 160 312   192 546  
Total dose of Gnt (IU) 2222 ± 819 a 2281 ± 633 a NS 2727 ± 664 b 3127 ± 674 b <  0.001
FSH use, % 57.5 58.3 NS 65.1 63.5 NS
Stimulation duration (d) 10.06 ± 1.60 9.82 ± 1.49 c NS 10.07 ± 1.79 10.18 ± 1.76 d NS
Mature follicle hCG day 3.4 ± 2.0 4.1 ± 2.7 a <  0.01 3.2 ± 1.8 2.5 ± 2.1 b <  0.001
Estradiol hCG day-2 1161 ± 530 1269 ± 528 <  0.05 1004 ± 335 1093 ± 460 <  0.05
Estradiol hCG day-1 1677 ± 607 1750 ± 723 NS 1472 ± 398 1464 ± 675 NS
Estradiol hCG day 1973 ± 613 a 1997 ± 689 a NS 1667 ± 531 b 1733 ± 722 b NS
Progesterone hCG day-2 0.73 ± 0.21 0.75 ± 0.30 NS 0.65 ± 0.17 0.79 ± 0.26 <  0.001
Progesterone hCG day-1 0.78 ± 0.29 0.90 ± 0.29 <  0.001 0.75 ± 0.27 0.84 ± 0.32 <  0.01
Progesterone hCG day 0.84 ± 0.22 0.99 ± 0.36 a <  0.001 0.83 ± 0.22 0.91 ± 0.31 b <  0.01
LH hCG day-2 2.17 ± 1.32 1.43 ± 1.23 <  0.001 1.68 ± 1.19 1.77 ± 1.32 NS
LH hCG day-1 1.73 ± 1.19 1.34 ± 1.28 <  0.01 1.37 ± 0.76 1.88 ± 1.65 <  0.001
LH hCG day 1.80 ± 1.47 1.49 ± 1.34 a <  0.05 1.61 ± 0.77 1.90 ± 1.27 b <  0.01
Endometrium (mm) 9.51 ± 1.49 e 9.62 ± 1.99 NS 9.98 ± 2.08 f 9.60 ± 1.86 NS
Stimulation cancelled 6 (3.7%) 12 (3.8%) NS 8 (4.1%) 28 (5.1%) NS
Number oocyte retrievals 154 300   184 518  
Retrieved oocytes (m ± SD) 9.10 ± 3.73 a 9.64 ± 4.09 a NS 6.77 ± 2.68 b 6.43 ± 3.03 b NS
Mature oocytes (m ± SD) 7.54 ± 2.73 a 7.84 ± 3.41 a NS 5.07 ± 2.31 b 4.71 ± 2.47 b NS
ICSI, % 57.1 a 57.0 a NS 64.6 b 69.1 b NS
2PN (m ± SD) 5.69 ± 2.26 a 5.87 ± 2.77 a NS 3.56 ± 2.11 b 2.96 ± 1.85 b <  0.01
Fertilization rate, % 75.5 74.9 a NS 70.2 62.5 b <  0.02
Total embryos (m ± SD) 5.75 ± 2.47 a 6.02 ± 2.68 a NS 3.54 ± 1.86 b 3.08 ± 1.75 b <  0.02
Cleavage rate, % 77.6 76.4 a NS 69.8 65.4 b NS
Blastocyst (m ± SD) 2.71 ± 1.74 2.62 ± 1.77 NS  
% Blastocyst/embryo 47.2 43.6 NS  
Culture failure 42 (27.2%) 76 (25.3%) NS 54 (29.3%) 135 (26.0%) NS
Number of transfers 112 224   130 383  
Embryos transferred (m ± SD) 1.33 ± 0.94 c 1.30 ± 0.92 c NS 1.59 ± 0.40 d 1.51 ± 0.89 d NS
  1. Legends: IU: international unit; Gnt: gonadotropin; endometrium: endometrial thickness
  2. Statistical analysis: The “p” column indicates the difference between pregnant and not pregnant women in cases of blastocyst or cleaved embryo transfer
  3. Difference between blastocyst and cleaved embryo transfers: a-b: p <  0.001, c-d: p <  0.01, e-f: p <  0.02, g-h: p <  0.05