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Table 4 Outcomes of neonates born following FET with different endometrial preparation protocols

From: Perinatal outcomes of neonates born from different endometrial preparation protocols after frozen embryo transfer: a retrospective cohort study

 

Singletons delivery

Multiple delivery

NC (N = 1491)

OS (N = 272)

HRT (N = 1234)

aOR (95%CI) a

aOR (95%CI) a

NC (N = 861)

OS (N = 176)

HRT (N = 698)

aOR (95%CI) a

aOR (95%CI) a

No. (%)

No. (%)

No. (%)

OS vs.NC

HRT vs. NC

No. (%)

No. (%)

No. (%)

OS vs.NC

HRT vs. NC

Gender

 Male

733 (49.16)

149 (54.78)

625 (50.65)

Reference

Reference

429 (49.83)

80 (45.45)

373 (53.44)

Reference

Reference

 Female

758 (50.84)

123 (45.22)

609 (49.35)

0.80 (0.62–1.04)

0.94 (0.80–1.10)

432 (50.17)

96 (54.55)

325 (46.56)

1.24 (0.89–1.73)

0.89 (0.73–1.10)

Birthweight

  < 2500 g

68 (4.56)

23 (8.46)

112 (9.08)

1.71 (1.02–2.87)

1.93 (1.39–2.68)

368 (42.74)

90 (51.14)

386 (55.30)

1.43 (1.03–1.99)

1.69 (1.37–2.08)

 2500-4000 g

1319 (88.46)

226 (83.09)

1031 (83.55)

Reference

Reference

493 (57.26)

86 (48.86)

312 (44.70)

Reference

Reference

  > 4000 g

104 (6.98)

23 (8.46)

91 (7.37)

1.19 (0.74–1.91)

1.01 (0.84–1.36)

0 (0.00)

0 (0.00)

0 (0.00)

NA

NA

Birthweight for gestational age

 SGA

104 (6.98)

32 (11.76)

126 (10.21)

1.58 (1.02–2.43)

1.27 (1.05–1.70)

127 (14.75)

35 (19.89)

203 (29.08)

1.39 (0.91–2.13)

2.33 (1.79–3.03)

 AGA

1037 (69.55)

189 (69.49)

857 (69.45)

Reference

Reference

689 (80.02)

136 (77.27)

464 (66.48)

Reference

Reference

 LGA

350 (23.47)

51 (18.75)

251 (20.34)

0.74 (0.52–1.03)

0.82 (0.67–1.01)

45 (5.23)

5 (2.84)

31 (4.44)

0.45 (0.16–1.21)

0.92 (0.55–1.54)

  1. FET frozen embryo transfer, NC natural cycles, OS ovarian stimulation, HRT hormonal replacement therapy, aOR adjusted odds ratio, CI confidence interval, NA not accessible, AGA appropriate for gestational age, SGA small for gestational age, LGA large for gestational age
  2. aaOR was adjusted for age at oocyte retrieval, age at embryo transfer, BMI, cause of infertility, gestational hypertensive disorder, intrahepatic cholestasis of pregnancy, and meconium staining of the amniotic fluid