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Table 4 Adjusted association of pregnancy and other clinical and demographic variables, with hospitalization, maximum length of hospital stay, moderate ventilation, invasive ventilation, and death, among COVID-19 associated female patients (18–44 years old)

From: The risk of clinical complications and death among pregnant women with COVID-19 in the Cerner COVID-19 cohort: a retrospective analysis

Variables

Hospitalization

Max LOS

(< 1 Day)

Max LOS

(> = 1 Day)

Moderate Ventilation

Invasive Ventilation

Death

aOR1 (95% CI)

\( {e}^{\hat{\beta}} \) 2 (95% CI)

\( {e}^{\hat{\beta}} \) 2 (95% CI)

aOR1 (95% CI)

aOR1 (95% CI)

aOR1 (95% CI)

Pregnant

  No

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

  Yes

12.26 (10.69, 14.06)

1.78 (1.67, 1.90)

0.90 (0.85, 0.95)

2.35 (1.48, 3.74)

0.89 (0.57, 1.40)

0.83 (0.30, 2.33)

Age (years) [5 years increment]3

1.07 (1.03, 1.10)

1.03 (1.02, 1.04)

1.04 (1.02, 1.06)

1.07 (0.96, 1.19)

1.19 (1.10, 1.28)

1.21 (1.05, 1.40)

Race and Ethnicity

 Non-Hispanic White

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

 Non-Hispanic American Indian or Alaska Native

1.43 (1.05, 1.94)

0.84 (0.77, 0.93)

1.47 (1.27, 1.70)

2.19 (0.99, 4.86)

3.83 (2.19, 6.70)

2.76 (1.12, 6.77)

 Non-Hispanic Asian or Pacific Islander

1.21 (0.93, 1.59)

1.02 (0.94, 1.11)

1.21 (1.06, 1.38)

0.75 (0.23, 2.48)

1.22 (0.65, 2.28)

1.58 (0.53, 4.73)

 Non-Hispanic Black or African American

0.91 (0.79, 1.04)

1.10 (1.06, 1.14)

1.07 (1.00, 1.14)

1.08 (0.69, 1.68)

0.79 (0.58, 1.08)

1.12 (0.63, 1.99)

 Non-Hispanic Other

1.09 (0.93, 1.28)

1.05 (1.02, 1.09)

1.01 (0.95, 1.07)

1.26 (0.75, 2.13)

0.86 (0.58, 1.27)

1.84 (0.93, 3.66)

 Hispanic or Latino

0.85 (0.75, 0.96)

0.99 (0.94, 1.03)

1.07 (1.00, 1.16)

0.92 (0.59, 1.42)

0.70 (0.51, 0.95)

0.83 (0.47, 1.48)

Insurance

 Private

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

 Government/Misc

0.82 (0.64, 1.06)

0.91 (0.85, 0.97)

0.97 (0.85, 1.11)

1.46 (0.61, 3.53)

1.06 (0.55, 2.05)

1.98 (1.16, 3.40)

 Medicaid

1.46 (1.30, 1.64)

1.15 (1.11, 1.19)

1.13 (1.07, 1.19)

1.36 (0.91, 2.03)

1.21 (0.91, 1.61)

2.01 (0.88, 4.60)

 Medicare

1.43 (1.06, 1.93)

1.29 (1.17, 1.43)

1.03 (0.92, 1.17)

1.03 (0.46, 2.28)

0.91 (0.54, 1.52)

1.39 (0.62, 3.11)

 Self-Pay

0.79 (0.67, 0.93)

0.98 (0.95, 1.02)

0.98 (0.90, 1.07)

1.45 (0.86, 2.47)

0.88 (0.57, 1.36)

1.39 (0.62, 3.11)

 Missing

2.00 (1.71, 2.33)

1.01 (0.96, 1.07)

1.19 (1.11, 1.27)

1.74 (1.05, 2.90)

2.10 (1.51, 2.93)

2.17 (1.16, 4.05)

Elixhauser AHRQ weighted Comorbidity Score [10 units increment]4

1.96 (1.84, 2.08)

1.12 (1.09, 1.14)

1.16 (1.13, 1.18)

1.37 (1.19, 1.57)

1.38 (1.32, 1.44)

3.15 (2.76, 3.61)

Gestational Diabetes

 No

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

 Yes

1.58 (1.24, 2.01)

0.98 (0.90, 1.07)

0.96 (0.87, 1.06)

0.86 (0.38, 1.94)

0.79 (0.41, 1.53)

–

Decadron and Prednisone

 No

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

 Yes

2.15 (1.78, 2.59)

1.28 (1.20, 1.36)

1.26 (1.17, 1.35)

2.49 (1.68, 3.69)

2.34 (1.77, 3.11)

–

Anticoagulant

 No

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

1 [Reference]

 Yes

72.73 (61.15, 86.50)

3.67 (3.27, 4.12)

1.36 (1.30, 1.43)

12.11 (8.53, 17.18)

13.76 (10.82, 17.50)

–

AUC

0.89

–

–

0.88

0.93

0.90

R2

–

0.12

0.15

–

–

–

  1. 1 Adjusted odds ratio from mixed-effect logistic regression model (clustering on one-digit zip-code)
  2. 2 adjusted exponentiated coefficients (mixed-effect exponential regression model clustering on one-digit zip-code) relating to percentage change in expected maximum length of hospital stay
  3. 3 Change in odds (or change in % of response for exponential model) for each 5 unit increase in predictor
  4. 4Change in odds (or change in % of response for exponential model) for each 10 unit increase in predictor