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Table 4 Maternal complications in the AFLP and HELLP syndrome groups

From: Comparison of maternal and neonatal outcomes between acute fatty liver of pregnancy and hemolysis, elevated liver enzymes and low platelets syndrome: a retrospective cohort study

 

AFLP versus HELLP syndrome

AFLP versus complete HELLP syndrome

 

AFLP

(n = 21)

HELLP syndrome

(n = 80)

P

Pa

Adjusted OR

(95 % CI)

AFLP

(n = 21)

Complete HELLP syndrome (n = 18)

P

Pa

Adjusted OR

(95 % CI)

Preeclampsiab

5 (23.8)

76 (95.0)

< 0.001*

< 0.001*

0.02

(0.01, 0.11)

5 (23.8)

16 (88.9)

< 0.001*

0.006*

0.03

(0.01, 0.35)

Preeclampsia with severe featuresb

1 (4.8)

76 (95.0)

< 0.001*

< 0.001*

0.01

(0.01, 0.03)

1 (4.8)

16 (88.9)

< 0.001*

0.002*

0.01

(0.01, 0.13)

Hypoglycemiab

6 (28.6)

2 (2.5)

0.001*

0.026*

11.28

(1.33, 95.66)

6 (28.6)

(12.8, 52.1)

1 (5.6)

(0.7, 33.4)

0.098

  

Jaundiceb

18 (85.7)

11 (13.8)

< 0.001*

< 0.001*

32.45

(6.12, 171.94)

18 (85.7)

5 (27.8)

< 0.001*

0.007*

14.94

(2.08, 107.29)

Pulmonary edemab

2 (9.5)

8 (10.0)

> 0.99

  

2 (9.5)

5 (27.8)

0.215

  

AKIb

13 (61.9)

12 (15.0)

< 0.001*

0.003*

6.78

(1.89, 24.32)

13 (61.9)

6 (33.3)

0.075

  

DICb

14 (66.7)

7 (8.8)

< 0.001*

< 0.001*

12.67

(3.11, 51.56)

14 (66.7)

1 (5.6)

< 0.001*

0.012*

21.27

(1.95, 231.64)

PPHb

2 (9.5)

10 (12.5)

> 0.99

  

2 (9.5)

4 (22.2)

0.387

  

Sepsisb

10 (47.6)

8 (10.0)

< 0.001*

0.036*

4.30

(1.10, 16.83)

10 (47.6)

4 (22.2)

0.099

  

Gastrointestinal bleedingb

1 (4.8)

0 (0)

0.208

  

1 (4.8)

0 (0)

> 0.99

  

Wound hematomab

2 (9.5)

2 (2.5)

0.190

  

2 (9.5)

1 (5.6)

> 0.99

  

Placental abruptionb

1 (4.8)

5 (6.3)

> 0.99

  

1 (4.8)

0 (0)

> 0.99

  

Blood transfusionb

8 (38.1)

17 (21.3)

0.111

  

8 (38.1)

6 (33.3)

0.757

  

Liver transplantationb

1 (4.8)

0 (0)

0.208

  

1 (4.8)

0 (0)

> 0.99

  

Postpartum eventb

1 (4.8)

10 (12.5)

0.451

  

1 (4.8)

4 (22.2)

0.162

  

Length of hospitalization (days)c

9 (7.0)

6 (5.8)

0.066

  

9 (7.0)

6.5 (7.0)

0.223

  

ICU admissionb

4 (19.0)

8 (10.0)

0.267

  

4 (19.0)

3 (16.7)

> 0.99

  

Maternal deathb

0 (0)

1 (1.3)

> 0.99

  

0 (0)

1 (5.6)

0.462

  
  1. AFLP acute fatty liver of pregnancy; HELLP hemolysis, elevated liver enzymes and low platelets; OR odds ratio; CI confidence interval; AKI acute kidney injury; DIC disseminated intravascular coagulopathy; PPH postpartum hemorrhage; ICU intensive care unit
  2. aP adjusted by BMI and twin pregnancy
  3. bChi-square or Fisher’s exact test, results are presented as number (percentage)
  4. cMann-Whitney U test, results are presented as median (interquartile range)
  5. *P < 0.05 was considered to be statistically significant