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Table 3 Quality of life assessed by the FertiQoL questionnaire and side effects of GnRHa and Dienogest pretreatment protocols before ART for endometriotic patients

From: Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial

 

GnRH agonist

Dienogest

P-value

Total FertiQoL score a

94.2 ± 11.5

105 ± 12.6

0.04

Overall quality of life a

2.9 ± 1.1

3.1 ± 0.7

0.78

Overall physical health satisfaction a

3.2 ± 0.6

3.1 ± 0.3

0.82

FertiQoL Core score a

71.8 ± 12.5

72.1 ± 13.5

0.67

 Emotional score

18.6 ± 8.3

18.2 ± 7.9

0.54

 Mind/Body score

17.4 ± 8.2

19.4 ± 8.8

0.77

 Relational score

18.9 ± 7.6

18.4 ± 7.3

0.67

 Social score

17.1 ± 6.2

17.5 ± 5.2

0.80

FertiQoL Treatment score a

25.1 ± 7.8

33.2 ± 6.2

< 0.001

 Tolerability

9.4 ± 2.3

14.1 ± 3.1

< 0.001

 Environment

16.6 ± 4.4

18.2 ± 3.7

0.15

Side effects b

40/67 (59.7%)

20/67 (29.9%)

< 0.001

  1. Side effects in the GnRH agonist included; hot flushes (n = 11), body aches (n = 6), sleep disturbances (n = 8), low mood (n = 8) and vaginal dryness (n = 7)
  2. Side effects in the Dienogest included; headache (n = 13) and Breast pain (n = 7)
  3. aValues are expressed as means ± standard deviations
  4. bValues expressed as numbers and percentages