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Table 3 Quality of life assessed by the FertiQoL questionnaire and side effects of GnRHa and Dienogest pretreatment protocols before ART for endometriotic patients

From: Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial

  GnRH agonist Dienogest P-value
Total FertiQoL score a 94.2 ± 11.5 105 ± 12.6 0.04
Overall quality of life a 2.9 ± 1.1 3.1 ± 0.7 0.78
Overall physical health satisfaction a 3.2 ± 0.6 3.1 ± 0.3 0.82
FertiQoL Core score a 71.8 ± 12.5 72.1 ± 13.5 0.67
 Emotional score 18.6 ± 8.3 18.2 ± 7.9 0.54
 Mind/Body score 17.4 ± 8.2 19.4 ± 8.8 0.77
 Relational score 18.9 ± 7.6 18.4 ± 7.3 0.67
 Social score 17.1 ± 6.2 17.5 ± 5.2 0.80
FertiQoL Treatment score a 25.1 ± 7.8 33.2 ± 6.2 < 0.001
 Tolerability 9.4 ± 2.3 14.1 ± 3.1 < 0.001
 Environment 16.6 ± 4.4 18.2 ± 3.7 0.15
Side effects b 40/67 (59.7%) 20/67 (29.9%) < 0.001
  1. Side effects in the GnRH agonist included; hot flushes (n = 11), body aches (n = 6), sleep disturbances (n = 8), low mood (n = 8) and vaginal dryness (n = 7)
  2. Side effects in the Dienogest included; headache (n = 13) and Breast pain (n = 7)
  3. aValues are expressed as means ± standard deviations
  4. bValues expressed as numbers and percentages