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Table 4 The area under ROC curve for HCA diagnosis with biomarkers

From: Biomarkers for a histological chorioamnionitis diagnosis in pregnant women with or without group B streptococcus infection: a case-control study

Population Biomarkers No. ROC area 95% Confidence Interval
Total pregnant TNF-α 366 0.841 0.778 0.904
IL-8 366 0.783 0.693 0.873
sICAM-1 366 0.717 0.590 0.844
Neutrophil ratio 366 0.742 0.605 0.879
WBC 366 0.683 0.524 0.842
CRP 366 0.712 0.559 0.866
Non-GBS infection TNF-α 309 0.898 0.814 0.982
IL-8 309 0.792 0.659 0.925
sICAM-1 309 0.664 0.469 0.858
Neutrophil ratio 309 0.815 0.646 0.985
WBC 309 0.849 0.721 0.977
CRP 309 0.796 0.646 0.946
GBS infection TNF-α 57 0.555 0.337 0.773
IL-8 57 0.461 0.237 0.684
sICAM-1 57 0.449 0.219 0.679
Neutrophil ratio 57 0.656 0.435 0.876
WBC 57 0.431 0.150 0.712
CRP 57 0.605 0.347 0.862
  1. Abbreviations: CRP C-reation protein, GBS Group B Streptococcus, HCA Histological chorioamnionitis, IL-8 Interleukin 8, sICAM-1 soluble Intercellular adhesion molecule-1, TNF-α Tumor necrosis factor α, WBC White blood cells