Biomarkers for a histological chorioamnionitis diagnosis in pregnant women with or without group B streptococcus infection: a case-control study

Table 4 The area under ROC curve for HCA diagnosis with biomarkers

Population	Biomarkers	No.	ROC area	95% Confidence Interval
Total pregnant	TNF-α	366	0.841	0.778	0.904
	IL-8	366	0.783	0.693	0.873
	sICAM-1	366	0.717	0.590	0.844
	Neutrophil ratio	366	0.742	0.605	0.879
	WBC	366	0.683	0.524	0.842
	CRP	366	0.712	0.559	0.866
Non-GBS infection	TNF-α	309	0.898	0.814	0.982
	IL-8	309	0.792	0.659	0.925
	sICAM-1	309	0.664	0.469	0.858
	Neutrophil ratio	309	0.815	0.646	0.985
	WBC	309	0.849	0.721	0.977
	CRP	309	0.796	0.646	0.946
GBS infection	TNF-α	57	0.555	0.337	0.773
	IL-8	57	0.461	0.237	0.684
	sICAM-1	57	0.449	0.219	0.679
	Neutrophil ratio	57	0.656	0.435	0.876
	WBC	57	0.431	0.150	0.712
	CRP	57	0.605	0.347	0.862

Abbreviations: CRP C-reation protein, GBS Group B Streptococcus, HCA Histological chorioamnionitis, IL-8 Interleukin 8, sICAM-1 soluble Intercellular adhesion molecule-1, TNF-α Tumor necrosis factor α, WBC White blood cells

ISSN: 1471-2393