Study ID and Location | Study Design | Number of Participants, n (singletons) | Maternal Age, mean ± SD number or % | Exposure | NOS Score |
---|---|---|---|---|---|
Anzola et al. (2019) [26] France | Retrospective hospital- based/ Matched | Fresh ET = 5883 Frozen ET= 366 SC = 6981 | Fresh ET 32.8 ± 4.4 Frozen ET 33.1 ± 4.3 SC not available | IVF and IVF + ICSI, Fresh ET or Frozen ET | 8 |
Apantaku et al. (2008) [27] England | Retrospective hospital- based/ Matched | ART = 88 SC = 88 | ART 33.5 + 4.0 SC-33.2 + 4.1 | IFV/ICSI | 8 |
Beyer et al. (2016) [40] Germany | Retrospective hospital- based | ART = 467 SC = 6417 | ART 33.7 + 4.0 SC 28 | ART (Fresh ET, Slow-rate Freezing, Vitrification) | 7 |
Buckett et al. (2007) [28] Canada | Retrospective hospital- based/ Matched | IVF = 133 ICSI = 104 SC = 338 | IVF 35 ICSI- 34 SC 34 | Fresh ET after IVF Fresh ET after ICSI | 9 |
Carbillon et al. (2017) [41] France | Retrospective hospital- based | IVF/ICSI = 119 SC = 7993 | Mild ovarian stimulation with ART- 30.2 + 5.9 Multi-follicular stimulation and ART- 29.9 + 6.0 SC - 29.7 + 5.8 | IFV/ICSI (Excluded oocyte donation, previous diabetes) | 7 |
Dayan et al. (2018) [42] Canada | Retrospective population-based | IVF = 1596 SC = 112,813 | IVF 35.7 ± 4.6 SC 30.3 ± 5.2 | IVF including (ICSI both fresh and frozen embryo transfer) | 9 |
D’Souza et al. (1997) [29] England | Prospective hospital-based/Matched | IVF = 150 SC = 150 | Not available | Fresh ET after IVF | 9 |
Ensing et al. (2015) [30] Netherlands | Retrospective population-based/ Matched/ adjusted | IVF = 16,177 SC = 1,905,011 | IFV 32.7 + 4.6 SC 32.7 + 4.5 | IVF as a subgroup | 9 |
Ernstad et al. (2016) [43] Sweden | Retrospective population-based | Fresh ET = 22,771 Frozen ET = 7795 SC = 1,196,394 | >  35 years All blastocyst (47.1%) All cleavage (45.7%) SC (20.4%) | Fresh ET after IVF Frozen ET after IVF (excluded oocyte donation) | 7 |
Farhi et al. (2013) [44] Israel | Prospective hospital-based | IVF = 202 ICSI = 307 SC = 587 | ART - 33.1 ± 4.9 SC - 30.1 ± 4.9 | ART (IVF and ICSI) | 6 |
Fedder et al. (2013) [18] Denmark | Retrospective population-based/ Matched/ adjusted | ICSI = 6156 IVF = 11,060 SC = 33,852 | ICSI (Group A = 32.78 + 4.27, Group B = 33.16 + 4.05) IVF (Group C): 34.01 + 4.04 SC (Group D): 30.23 + 4.86 | IVF and ICSI | 9 |
Gambadauro et al. (2017) [45] Sweden | Prospective population-based | IVF = 167 SC = 3116 | >  35 years IVF 46.1% SC 22.6% | IVF with or without ICSI | 7 |
Gillet et al. (2011) [31] Belgium | Retrospective population-based/Matched | IVF/ICSI = 1866 SC = 15,228 | IVF/ICSI − 37.8 ± 2.4 SC 37.3 ± 2.0 | IFV/ICSI | 9 |
Harlev et al. (2018) [46] Israel | Retrospective hospital- based | IVF = 229 SC = 7929 | IVF 41 + 1.35 SC 41 + 1.20 | IVF and Ovulation induction | 9 |
Katalinic et al. (2004) [19] Germany | Prospective hospital-based | ICSI = 2055 SC = 7861 | ICSI 32.9 + 3.9 SC 27.0 + 4.7 | Fresh embryo transfer (ET) after ICSI | 7 |
Koudstaal et al. (2000) [20] Netherlands | Retrospective hospital- based/ Matched | IVF = 307 SC = 307 | IVF 32.8 (+  4.3) SC 32.7 + (4.4) | Fresh ET after IVF (excluded frozen and embryo reduction) | 9 |
Liu et al. (2015) [53] China | Retrospective hospital- based | IVF = 380 SC = 405 | IVF/ICSI 31.59 ± 3.48 years SC 31.31 ± 3.45 years | IVF/ICSI | 4 |
Malchau et al. (2014) [47] Denmark | Retrospective population-based | IVF = 4135 ICSI = 3635 SC = 229,749 | IVF 34.2 (+ 4.4) ICSI 33.4 (+ 4.3) SC 30.7 (+ 4.9) | IUI IVF and ICSI | 9 |
Ochsenkuhn et al. (2003) [32] Germany | Retrospective hospital- based/ Matched/ adjusted | IVF = 163 SC = 322 | IVF 32.6 SC 32.2 | IVF GIFT | 9 |
Olivennes et al. (1993) [21] France | Retrospective hospital- based | IVF = 162 SC = 5096 | IVF 33.6 ± 3.9 SC 29.9 ± 4.7 | IVF | 7 |
Olson et al. (2005) [33] United States | Retrospective hospital- based/ Matched | IVF/ICSI = 645 SC = 4590 | IVF 33.9 + 4.6 SC 33.3 + 4.3 | IVF/ICSI | 8 |
Perri et al. (2001) [34] Israel | Retrospective hospital- based/ Matched | ART = 95 SC = 190 | ART 32.15 + 4.5 SC 32.13 + 4.5 | IFV/ICSI Transferring both IVF- and ICSI-derived embryos | 9 |
Pinborg et al. (2010) [35] Denmark | Retrospective population-based/ Matched/ adjusted | Frozen = 957 Fresh =10,329 Non-ART = 4800 | Frozen 34.0 (3.8) Fresh 33.7 (4.0) Non-ART 30.1 (4.8) | Frozen ET after IVF/ICSI Fresh ET after IVF/ICSI | 8 |
Poikkeus et al. (2007) [36] Finland | Retrospective hospital- based/ Matched/ adjusted | IVF/ICSI = 499 (SET = 269; DET = 230) SC = 15,037 | Single ET 32.6 + 3.9 Double ET 34.2 + 3.8 SC 30.3 + 5.3 | IFV/ICSI (Single ET or Double ET) | 8 |
Rahu et al. (2019) [48] Estonia | Retrospective population-based | IVF/ICSI = 1778 SC = 33,555 | IVF/ICSI 32.5 ± 3.8 SC 28.6 ± 3.3 | IVF/ICSI, autologous | 9 |
Romundstad et al. (2008) [49] Norway | Retrospective population-based | ART = 8229 SC = 1,200,922 | All ranges, and ≥35 years ART 35% SC 12% | IFV/ICSI | 9 |
Sazonova et al. (2012) [50] Sweden | Retrospective population-based | Frozen = 2348 Fresh = 8944 SC = 571,914 | n 30–39 ART = 8754 SC = 297,818 n ≥ 40 ART = 836 SC = 18,096 | Frozen ET after IVF/ICSI Fresh ET after IVF/ICSI (excluded oocyte donation) | 9 |
Shevell et al. (2005) [22] United States | Prospective hospital-based | ART = 554 SC = 34,286 | IVF 34.5 (+ 5.2) SC 29.9 (+ 5.7) | IVF ICSI GIFT/ZIFT | 8 |
Stojnic et al. (2013) [37] Serbia | Retrospective hospital- based/ Matched / adjusted | IVF = 351 ICSI = 283 SC = 634 | IVF/ICSI 36 ± 4.2 SC 35 ± 4.1 | IVF/ICSI (excluded oocyte donation, frozen and vanishing twins) | 9 |
Sun et al. (2014) [38] Canada | Retrospective hospital- based/ Matched/adjusted | ART = 1327 SC = 5222 | All ranges, and ≥ 35 years: ART 51% SC 50% | IFV/ICSI | 9 |
Suzuki et al. (2007) [51] Japan | Retrospective hospital- based | IVF-ET = 89 SC = 849 | All ≥35 years | IVF/ICSI | 8 |
Tomic et al. (2011) [39] Croatia | Retrospective hospital- based/ Matched | IVF = 283 SC = 283 | IVF = 37.8 ± 3.9 SC = 37.4 ± 3.8 | IVF in advanced age (excluded oocyte donation, cryopreservation, vanishing twins) | 9 |
Toshimitsu et al. (2014) [52] Tokyo | Retrospective hospital- based | IVF/ICSI = 116 SC = 662 | IVF/ICSI41.5 ± 1.5 SC 41.2 ± 1.4 | IVF/ICSI, autologous | 7 |
Wennerholm et al. (2013) [23] Denmark, Norway and Sweden | Retrospective population-based/Matched/ adjusted | Frozen ET = 6647 Fresh ET = 42,242 SC = 288,542 | Frozen: 33.7 + 3.9 Fresh: 33.3 + 4.0 SC:28.5 + 5.0 | Frozen ET after IVF/ICSI | 9 |