Association of term isolated microcephaly with mode of delivery and perinatal outcome - a retrospective case-control analysis

Table 3 Neonatal outcomes in 3677 fetuses stratified by head circumference

Parameter	Normal HC	Microcephaly	p-Value
N	3651	26
Neonatal sex, male	1230/2552 (48.2%)	18/20 (90.0%)	<.001
Neonatal birthweight, g	3323.2 ± 432.2	2957.0 ± 330.4	<.001
Neonatal birthweight, centile	60.5 ± 26.4	33.6 ± 21.5	<.001
5-min Apgar score < 7	32	0	0.631
Jaundice	420/3651 (11.5%)	5/26 (19.2%)	0.215
Phototherapy	75/3651 (2.1%)	1/26 (3.9%)	0.420
Asphyxia	42/3651 (1.2%)	0	1.000
NICU admission	189/3639 (5.2%)	3/26 (11.5%)	0.153
Seizure	7/3651 (0.2%)	0	1.000
Intraventricular hemorrhage	7/3651 (0/2%)	0	1.000
Transient tachypnea of the newborn	34/3651 (0.9%)	0	1.000
Respiratory distress syndrome	8/3651 (0.2%)	0	1.000
Neonatal sepsis	9/3651 (0.3%)	0	1.000
Composite outcome^a	241/3651 (6.6%)	3/26 (11.5%)	0.420

Data are presented and mean and standard deviation for continuous variables and number and percent for categorical variables
NICU Neonatal intensive care unit
^aComposite outcome – any one of the following: NICU admission, intraventricular hemorrhage, 5-min Apgar score < 7, asphyxia, seizures, and sepsis

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