Skip to main content

Table 3 Summary of reported cases of disseminated intravascular coagulation (DIC) or coagulopathy in pregnant women with confirmed COVID-19

From: Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis

  Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Case 7 Case 8 Case 9 Case 10
Study number 48 (Canada) 48 67 67 50 118 NUH/UHL 155 101 81
Classification of coagulopathy DIC in pregnancy score 27 DIC in pregnancy score 27 Authors stated DIC Authors stated coagulopathy Authors state mild coagulopathy. DIC in pregnancy score 27 Authors stated coagulopathy Authors stated DIC Authors stated DIC DIC in pregnancy score 27 Authors stated DIC
Maternal outcome Recovered Recovered Died Remains in Hospital Remains on ICU Died Died Recovered
(after termination of pregnancy)
Remains in hospital Recovered
Haematological indices Platelets (minimum and maximum if multiple values reported) 82 54 122–188 122–170 114 40–119 57 33–94 required “10 injections of platelets) 57
APTT (normal range) 41 (18.5–29.9) 60 (28.0–41.9)    35.1 PTT 30.1–30.6 49.3 (24–33) PTT 44.6–27.7 PTT 36  
Prothrombin Time      20.2 10.6–10.9 23.9 12.7 16  
INR 1.0 1.1    1.7 0.94–0.97 1.8    
Fibrinogen (g/L)
Normal 2.48–5.06 (3rd trimes ster)
2.2 0.8      1.1 Mg/dL < 60–275   
D Dimer (mg/L) normal 0.13–1.7 25.79 > 20     6.5 19.06 > 33.89   
Minimum ISTH Pregnancy DIC Score with available values 27 27    27   N/A (postpartum) 26 27  
Minimum DIC score (ISTH) 4 5     2 6 6   
  1. 1Few papers specifically stated negative findings for coagulopathy or thrombosis. Cases were therefore considered negative for these events if it was stated that there were no complications during the observed clinical course, or if patients were stated to have recovered/be recovering, or discharged without mention of coagulopathy or thrombosis