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Table 3 Summary of reported cases of disseminated intravascular coagulation (DIC) or coagulopathy in pregnant women with confirmed COVID-19

From: Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis

 

Case 1

Case 2

Case 3

Case 4

Case 5

Case 6

Case 7

Case 8

Case 9

Case 10

Study number

48 (Canada)

48

67

67

50

118

NUH/UHL

155

101

81

Classification of coagulopathy

DIC in pregnancy score 27

DIC in pregnancy score 27

Authors stated DIC

Authors stated coagulopathy

Authors state mild coagulopathy. DIC in pregnancy score 27

Authors stated coagulopathy

Authors stated DIC

Authors stated DIC

DIC in pregnancy score 27

Authors stated DIC

Maternal outcome

Recovered

Recovered

Died

Remains in Hospital

Remains on ICU

Died

Died

Recovered

(after termination of pregnancy)

Remains in hospital

Recovered

Haematological indices

Platelets (minimum and maximum if multiple values reported)

82

54

122–188

122–170

114

40–119

57

33–94

required “10 injections of platelets)

57

APTT (normal range)

41 (18.5–29.9)

60 (28.0–41.9)

  

35.1

PTT 30.1–30.6

49.3 (24–33)

PTT 44.6–27.7

PTT 36

 

Prothrombin Time

    

20.2

10.6–10.9

23.9

12.7

16

 

INR

1.0

1.1

  

1.7

0.94–0.97

1.8

   

Fibrinogen (g/L)

Normal 2.48–5.06 (3rd trimes ster)

2.2

0.8

    

1.1

Mg/dL < 60–275

  

D Dimer (mg/L) normal 0.13–1.7

25.79

> 20

   

6.5

19.06

> 33.89

  

Minimum ISTH Pregnancy DIC Score with available values

27

27

  

27

 

N/A (postpartum)

26

27

 

Minimum DIC score (ISTH)

4

5

   

2

6

6

  
  1. 1Few papers specifically stated negative findings for coagulopathy or thrombosis. Cases were therefore considered negative for these events if it was stated that there were no complications during the observed clinical course, or if patients were stated to have recovered/be recovering, or discharged without mention of coagulopathy or thrombosis