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Table 4 Adverse obstetric and neonatal outcomes stratified by timing of diagnosis and the three most frequent cancer site. Lombardy, Italy. 2008–2017

From: Obstetric and neonatal outcomes in women with pregnancy associated cancer: a population-based study in Lombardy, Northern Italy

 

During Pregnancy Cancers

Post-pregnancy Cancer

 

Breast

N=69

Thyroid

N=17

Lymphoma

N=18

Breast

N=190

Thyroid

N=121

Lymphoma

N=85

Obstetric outcomes

 Labor induction or planning of delivery b

  Not Induced

12 (17.9)

8 (47.1)

3 (17.6)

109 (58.0)

66 (55.0)

52 (61.2)

  Induced or Elective CS

55 (82.1)

9 (52.9)

14 (82.4)

79 (42.0)

54 (45.0)

33 (38.8)

 

p value a = 0.048

p value = 0.675

 Mode of Delivery c

  Vaginal or Instrumental

31 (44.9)

12 (70.6)

6 (35.3)

129 (57.9)

88 (72.7)

58 (69.1)

  CS

38 (55.1)

5 (29.4)

11 (64.7)

61 (32.1)

33 (27.3)

26 (30.9)

 

p value = 0.089

p value = 0.659

 Timing of Birth

  At Term

33 (47.8)

14 (82.4)

10 (55.6)

170 (89.5)

111 (91.7)

79 (92.9)

  Preterm

36 (52.2)

3 (17.6)

8 (44.4)

20 (10.5)

10 (8.3)

6 (7.1)

 

p value = 0.037

p value = 0.607

Neonatal outcomes

 SGA

  No

69 (100.0)

16 (94.1)

16 (88.9)

172 (90.5)

116 (95.9)

74 (87.1)

  Yes

0 (0.0)

1 (5.9)

2 (11.1)

18 (9.5)

5 (4.1)

11 (12.9)

 

p value a = 0.036

p value = 0.071

 Apgar 5th Minute

  Normal

66 (95.6)

17 (100.0)

18 (100.0)

188 (99.0)

120 (99.2)

85 (100.0)

  Low

3 (4.4)

0 (0.0)

0 (0.0)

2 (1.0)

1 (0.8)

0 (0.0)

 

p value a = 1.000

p value a = 1.000

 Malformation

  No

69 (100.0)

17 (100.0)

18 (100.0)

190 (100.0)

119 (98.4)

85 (100.0)

  Yes

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

2 (1.6)

0 (0.0)

 

p value a = 0.139

 Perinatal Mortality

  Livebirth

69 (100.0)

17 (100.0)

18 (100.0)

190 (100.0)

120 (99.2)

85 (100.0)

  Stillbirth

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

1 (0.8)

0 (0.0)

 

p value a = 0.520

  1. CS cesarean section
  2. ausing Fisher’s Exact Test
  3. bNot including 3 missing data among the non-pregnancy cancer associated women and 3 missing data among the pregnancy cancer associated women
  4. cNot including 1 missing data among the non-pregnancy cancer associated women and 1 missing data among the pregnancy cancer associated women