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Table 3 Association between genotype variants and clinical and biochemical parameters in LOPE groups

From: Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

SNP ID Model (n) BMI TC TG HDL LDL TG/HDL TSH T3 T4
rs2232365(C/T) TT + CT(82) 29.01(26.63–34.05) 5.80(5.06–7.06) 3.72(2.81–4.66) 1.61(1.33–1.95) 2.91(2.36–3.72) 2.35(1.64–3.23) 3.29(2.31–5.42) 4.05(3.49–4.48) 12.14(10.59–14.24)
  CC(25) 29.88(28.26–31.96) 6.21(5.22–6.75) 3.30(2.89–3.99) 1.77(1.63–2.10) 2.97(2.46–3.58) 1.88(1.52–2.32) 4.44(3.18–5.19) 3.93(3.45–4.58) 12.00(10.74–12.64)
  P 0.219 0.688 0.118 0.040* 0.874 0.016* 0.475 0.953 0.371
rs3853839(C/G) CC + CG(44) 30.17(26.83–34.18) 5.64(4.67–6.47) 3.51(2.84–4.50) 1.55(1.30–1.86) 2.77(2.38–3.44) 2.32(1.84–2.88) 3.84(2.06–5.75) 4.38(3.86–4.98) 12.08(10.33–13.27)
  GG(63) 29.00(26.91–32.43) 6.21(5.22–7.06) 3.60(2.84–4.59) 1.74(1.49–2.07) 3.02(2.45–3.93) 2.09(1.48–3.03) 3.68(2.62–5.31) 3.87(3.35–4.38) 12.00(10.90-13.64)
  P 0.296 0.141 0.648 0.063 0.222 0.425 0.894 0.005* 0.423
rs3761548(T/G) GG + TG(102) 29.10(26.76–32.77) 5.96(5.06–7.02) 3.57(2.81–4.51) 1.67(1.38–1.97) 2.95(2.39–3.77) 2.18(1.53–2.92) 3.70(2.39–5.43) 4.02(3.45–4.52) 12.08(10.58–13.54)
  TT(5) 34.29(29.24–35.20) 6.57(5.46–6.75) 3.60(3.35–4.96) 1.78(1.62–2.13) 2.77(2.70–3.10) 2.72(1.94–2.79) 3.65(1.96–4.74) 3.98(3.87–4.58) 12.00(11.86–12.02)
  P 0.083 0.831 0.456 0.560 0.745 0.626 0.658 0.935 0.859
  1. LOPE represents late-onset preeclampsia, BMI Body mass index, TSH Thyroid-stimulating hormone, FT3 Free triiodothyronine, FT4 Free thyroxine, TC Total cholesterol, TG Triglyceride, HDL-C High-density lipoprotein, LDL-C Low-density lipoprotein, TG/HDL Triglyceride/ high-density lipoprotein. *P < 0.05 versus controls