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Table 3 Association between genotype variants and clinical and biochemical parameters in LOPE groups

From: Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

SNP ID

Model (n)

BMI

TC

TG

HDL

LDL

TG/HDL

TSH

T3

T4

rs2232365(C/T)

TT + CT(82)

29.01(26.63–34.05)

5.80(5.06–7.06)

3.72(2.81–4.66)

1.61(1.33–1.95)

2.91(2.36–3.72)

2.35(1.64–3.23)

3.29(2.31–5.42)

4.05(3.49–4.48)

12.14(10.59–14.24)

 

CC(25)

29.88(28.26–31.96)

6.21(5.22–6.75)

3.30(2.89–3.99)

1.77(1.63–2.10)

2.97(2.46–3.58)

1.88(1.52–2.32)

4.44(3.18–5.19)

3.93(3.45–4.58)

12.00(10.74–12.64)

 

P

0.219

0.688

0.118

0.040*

0.874

0.016*

0.475

0.953

0.371

rs3853839(C/G)

CC + CG(44)

30.17(26.83–34.18)

5.64(4.67–6.47)

3.51(2.84–4.50)

1.55(1.30–1.86)

2.77(2.38–3.44)

2.32(1.84–2.88)

3.84(2.06–5.75)

4.38(3.86–4.98)

12.08(10.33–13.27)

 

GG(63)

29.00(26.91–32.43)

6.21(5.22–7.06)

3.60(2.84–4.59)

1.74(1.49–2.07)

3.02(2.45–3.93)

2.09(1.48–3.03)

3.68(2.62–5.31)

3.87(3.35–4.38)

12.00(10.90-13.64)

 

P

0.296

0.141

0.648

0.063

0.222

0.425

0.894

0.005*

0.423

rs3761548(T/G)

GG + TG(102)

29.10(26.76–32.77)

5.96(5.06–7.02)

3.57(2.81–4.51)

1.67(1.38–1.97)

2.95(2.39–3.77)

2.18(1.53–2.92)

3.70(2.39–5.43)

4.02(3.45–4.52)

12.08(10.58–13.54)

 

TT(5)

34.29(29.24–35.20)

6.57(5.46–6.75)

3.60(3.35–4.96)

1.78(1.62–2.13)

2.77(2.70–3.10)

2.72(1.94–2.79)

3.65(1.96–4.74)

3.98(3.87–4.58)

12.00(11.86–12.02)

 

P

0.083

0.831

0.456

0.560

0.745

0.626

0.658

0.935

0.859

  1. LOPE represents late-onset preeclampsia, BMI Body mass index, TSH Thyroid-stimulating hormone, FT3 Free triiodothyronine, FT4 Free thyroxine, TC Total cholesterol, TG Triglyceride, HDL-C High-density lipoprotein, LDL-C Low-density lipoprotein, TG/HDL Triglyceride/ high-density lipoprotein. *P < 0.05 versus controls