Accelerated fetal growth in early pregnancy and risk of preterm birth: a prospective cohort study

Table 3 Growth in early pregnancy and risk of preterm birth, very preterm and moderate preterm birth. (N = 2838 births)

Growth at second trim scan	All preterm births (n = 2838)			Very preterm births (n = 378)			Moderate preterm births (n = 2460)
	No. of women	Odds ratio (95% CI)		No. of women	Odds ratio (95% CI)		No. of women	Odds ratio (95% CI)
	No. of women	Crude	Adjusted^d	No. of women	Crude	Adjusted^d	No. of women	Crude	Adjusted^d
Accelerated fetal growth^a	389	1.39 (1.25–1.56)^*	1.36 (1.20–1.54)^*	52	1.38 (1.01–1.86)^**	1.33 (0.96–1.83)^**	337	1.39 (1.24–1.57)^*	1.36 (1.18–1.55)^*
Appropriate fetal growth^b	2215	Ref	Ref	295	Ref	Ref	1920	Ref	Ref
Delayed fetal growth^c	234	0.85 (0.73–0.96)^*	0.84 (0.71–0.97)^*	31	0.84 (0.58–1.21)^***	0.73 (0.47–1.12)^***	203	0.84 (0.72–0.97)^*	0.85 (0.73–1.00)^*

^aAccelerated fetal growth at second trimester scan was defined as BPD measurement at the 90th percentile, or more of the expected for gestational age
^bAppropriate fetal growth at second trimester scan was defined as BPD measurement between 10th -90th percentile of the expected for gestational age
^cDelayed fetal growth at second trimester scan was defined as BPD measurement at the 10th percentile, or less of the expected for gestational age
^dAdjusted OR for maternal age older than 35 yrs., short maternal height < 155 cm, BMI ≥ 30 kg/m², non-Nordic origin, primiparity, smoking, IVF, pre-gestational diabetes mellitus, chronic hypertension and male fetal gender
^*p < 0.0001
^**p < 0.05
^***p > 0.05

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